The assessment of endogenous glucose production and insulin-stimulated glucose disposal in type 2 diabetes patients using a euglycemic insulin clamp technique with [6,6-2D2]glucose infusion, non-randomized intergroup trial
Phase 1
- Conditions
- Type 2 diabetes
- Registration Number
- JPRN-UMIN000016259
- Lead Sponsor
- Tokyo University faculty of Medicine Department of Diabetes and Endocrinology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Not provided
Exclusion Criteria
1) Patients with known bleeding disorders. 2) Type 1 diabetes and secondary diabetes patients. 3) Patients with severe renal disease(s-Cre > 2.0 mg/dl). 4) Patients with severe liver disease (AST or ALT > 100 IU/L). 5) Patients who are unable to be responsible for informed consent due to severe psychiatric disease. 6) Excessive common custom drinker (alcohol > 100 ml/day). 7) Patients who have a history of hypersensitivity. 8) Pregnant or possibly pregnant women. 9) Women on lactation. 10) In addition, patients who were judged inappropriate by an attendant physician.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Endogenous glucose production and insulin-stimulated glucose disposal.
- Secondary Outcome Measures
Name Time Method 1) Suppression of endogenous glucose production by insulin. 2) Plasma glucose, plasma insulin, C-peptide and free fatty acid. 3) The association of fasting plasma glucose, HbA1c, HOMA-IR, HOMA-beta, CPI, hepatic function, blood-cholesterol level and hematological value with endogenous glucose production and insulin-stimulated glucose disposal. 4) Safety