The Intensive Care Muscle imaging study
- Conditions
- Intensive care unit acquired weaknessMusculoskeletal DiseasesMuscle wasting and atrophy, not elsewhere classified
- Registration Number
- ISRCTN17829967
- Lead Sponsor
- niversity of Edinburgh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 30
Group 1 (10 patients):
1. Adult ICU survivors
2. Ventilated for 48 hours or more
3. Good level of physical function prior to hospital admission (Rivermead Mobility Index (RMI) >/14 at any time in the week prior to hospital admission)
4. Within 7 days of ICU discharge
5. Evidence of very poor physical recovery (RMI =8)
Group 2 (10 patients):
1. Adult ICU survivors
2. Paired by age, gender and body mass index (BMI) to Group 1
3. Ventilated for 48 hours or more
4. Good level of physical function prior to hospital admission (RMI =15 at any time in the week prior to hospital admission)
5. Within 7 days of ICU discharge
6. Evidence of very good physical recovery (RMI = 9)
Group 3 (10 patients):
1. A healthy community based sample derived from patients presenting for day case surgery.
2. Paired by age, gender, and BMI to groups 1 and 2
3. Good level of physical function (RMI = 15)
Exclusion criteria for groups 1 and 2:
1. <18 years of age
2. Patient receiving palliative care
3. Patient has a contraindication to MRI imaging
4. Neurological diagnosis
5. Background chronic neuromuscular disease
6. Patient lacks mental capacity
7. Malignancy
8. Chronic inflammatory disease
9. Clinical instability
Exclusion criteria for group 3
1. <18 years
2. Malignancy
3. Chronic inflammatory disease
4. Background chronic neuromuscular disease
5. Neurological diagnosis
6. Presenting for lower limb arthroplasty
7. Patient lacks mental capacity
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method