Eccentric Cycling Exercise on Hemodynamic and Hemorheologic Properties
- Conditions
- Eccentric Exercise Training
- Interventions
- Behavioral: Concentric cycling trainingBehavioral: Eccentric cycling training
- Registration Number
- NCT04773444
- Lead Sponsor
- Chang Gung Memorial Hospital
- Brief Summary
The effects of an eccentric endurance training on central and peripheral hemodynamic adaptations and erythrocyte rheology during maximal exercise remained to be unexplored. The current study examined the contribution of rheological functions and/or hemodynamic adaptation to changes in oxygen consumption (VO2) following the matched-power output eccentric (ECT) or concentric cycling training (CCT).
Method: A total of 39 sedentary males were randomly assigned into either CCT (n=13) or ECT (n=13) for 30 min a day, 5 days a week for 6 weeks at 60% of maximal workload or to a CTL (control group, n = 13). A graded exercise test (GXT) was performed before and after the intervention. Central and microvascular adaptations were evaluated using thoracic impedance and near-infrared spectroscopy (NIRS), respectively. Rheological characteristics was determined by an ektacytometer.
- Detailed Description
Endurance training is a well known strategy for improving fitness capacity. However, some populations are intolerance to complete the usual exercise training program, such as chronic heart or pulmonary disease or the elderly. Therefore, ECT is a candidate training strategy for those individuals.
Erythrocytes deformability is significantly related to the blood perfusion in microcirculation. The impaired erythrocyte-related rheology further lead to reduced aerobic capacity by our research team. Therefore, the lower energy consumed in ECT may avoid the oxidative stress. To now, less studies have demonstrated whether ECT influences peripheral hemodynamics by erythrocyte rheology and the blood flow from the central effect.
The investigators aimed to investigate the effects of CCT and ECT on oxygen consumption response explained by changes in local blood perfusion, blood cell rheology, or central function to attempt developing its application in rehabilitation.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 60
- in sedentary lifestyle, who were nonsmokers, nonusers of medications/vitamins, and free of any cardiopulmonary/hematological risks
- regular exercise habits (i.e., exercise frequency once per week, duration >20 min).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Concentric cycling training Concentric cycling training Moderate intensity cycling training in concentric type (intensity matched the eccentric training) Eccentric cycling training Eccentric cycling training Moderate intensity cycling training in eccentric type
- Primary Outcome Measures
Name Time Method Central and peripheral hemodynamics 12 weeks Evaluate cardiac and peripheral hemodynamic response to exercise by using noninvasive continuous cardiac output monitoring system and near-infrared spectroscopy (NIRS).
- Secondary Outcome Measures
Name Time Method Erythrocyte rheological characteristics 12 weeks Isolated erythrocyte first, then detect the cell geometric shape by using the FACSCalibur.
To assess erythrocyte deformability and aggregation by using laser assisted optical rotational red cell analyzer (LoRRca).Cardiopulmonary fitness 12 weeks The graded exercise test (GXT) on a bicycle ergometer was performed. The GXT comprised 2 min of unloaded pedaling followed by a continuous increase in the work rate of 30 watt per 3-minute until exhaustion (i.e., progressive exercise to maximal O2 consumption)
Trial Locations
- Locations (1)
Chang Gung University
🇨🇳Taoyuan, Taiwan