Eccentric Resistance Training Among Individuals With Chronic Heart Failure
- Conditions
- Heart Failure
- Interventions
- Other: Eccentric Resistive Training + Aerobic training GroupOther: Resistance Training + Aerobic training GroupOther: Aerobic training Group
- Registration Number
- NCT06032780
- Lead Sponsor
- Riphah International University
- Brief Summary
To determine the effects of eccentric resistive training on ventricle functions and aerobic capacity as compared to a resistance and aerobic training among Heart failure (HF)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 84
- Patient able to safely perform lower limb exercise will be check by six- minute walk test (6 MWT)
- Diagnosis of Chronic HF and currently on optimal medical therapy
-
Already participating in cardiac rehabilitation
- New York Heart Association (NYHA) Classification of HF class IV HF symptoms
- Co-existent other disease such as asthma/ COPD/interstitial lung disease.
- Symptomatic Second degree or third degree heart block.
- ECG with uncontrolled ventricular arrhythmia
- limited Exercise ability due to neurologic or orthopedic impairments of the legs (will cross-check with 6 MWT)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Eccentric Resistive Training + Aerobic training Group Eccentric Resistive Training + Aerobic training Group - Resistance Training + Aerobic training Group Resistance Training + Aerobic training Group - Aerobic training Group Aerobic training Group -
- Primary Outcome Measures
Name Time Method Aerobic Capacity 12 week Changes will be measured at baseline, 4th week, 8th week and 12th week. The 6-min walk test provides an indirect measure of cardiovascular functional/aerobic capacity. Six Minute Walk test (6MWT) will be used to assess the functional capacity of the individuals with HF. The subjects will be instructed to walk for 6 minutes at a given time along a 30-m line at an interval of 1.5 m in an outdoor corridor, and the distance walked will be recorded in meters. The participants will be encouraged to continue walking as fast as possible. Then a generalized equation will be used to predict peak VO2 from 6 minute walk distance (6MWD) with the help of formula. Mean Peak VO2 (ml/kg/Mean) = 4.948 + 0.023 \*Mean 6MWD (meters)
Ventricle Functions 12 week Changes from the baseline will be measured. Doppler resting echocardiography will be performed to measure ventricle functions. Standard views, including the parasternal long-axis, short-axis at the papillary muscle level, and apical 4- and 2-chamber views will be recorded. Left ventricular ejection fraction (LVEF) and end systolic and end-diastolic diameters (LVESD and LVEDD) will be measured using formula (Tiecholz formula i-e spherical volume of the heart multiplied by a correction factor). Any structural changes will also be recorded.
- Secondary Outcome Measures
Name Time Method Quality of life (Minnesota Living with Heart Failure Questionnaire) 12 week Changes from the baseline will be measured. Quality of life will be measured through Minnesota Living with Heart Failure Questionnaire (MLHFQ). It is one of the most widely used health-related quality of life questionnaires for individuals with HF. It provides scores for two dimensions, physical and emotional, and a total score. The MLHFQ is a self-administered, 21-item disease-specific instrument for individuals with HF. Each item is scored in a 6-point Likert Scale (0 to 5), thus the total score could range from 0 to 105, with higher scores indicating more significant impairment in health-related quality of life. The MLHFQ has two domains; physical domain (eight items, score range from 0 to 40) and emotional domain (five items, score range from 0 to 25).
Maximal strength of respiratory muscles 12 week Changes will be measured at baseline, 4th week, 8th week and 12th week. Maximum Inspiratory pressure (MIP) and Maximal Expiratory pressure (MEP) will be assessed through a handheld mouth pressure meter.
Cardiac Risk Factors - Blood Pressure 12 week Changes from the Baseline, Blood pressure (Bp) (both systolic/diastolic) will be measured in mmHg. It will be measured manually through sphygmomanometer by trained assessor in sitting position at baseline and at end of training on each week (for safety check).
Cardiac Risk Factors - Body mass index 12 week Changes will be measured at baseline, 6th week and at 12th week. Weight in kilograms (kg) and Height in meters (m) will be combined to report BMI in kg/m\^2 to measure the Body mass index
Strength 12 week Changes will be measured at baseline, 4th week, 8th week and 12th week. Maximum muscle strength of the all major muscles biceps, triceps, quadriceps and hamstring, will be measured in sitting position with (MicroFET2 Digital Handheld Dynamometer muscle tester).
Peak Expiratory Flow (PEF) 12 week Changes will be measured at baseline, 4th week, 8th week and 12th week, the digital spirometer is used in clinical setting to analyze peak expiratory flow PEF in Liter/second.
Forced Expiratory Volume in 1 second (FEV1) 12 week Changes will be measured at baseline, 4th week, 8th week and 12th week, the digital spirometer is used in clinical setting to analyze Forced Expiratory Volume in 1 second FEV1 in Liters
Forced vital Capacity (FVC) 12 week Changes will be measured at baseline, 4th week, 8th week and 12th week, the digital spirometer is used in clinical setting to analyze Forced vital Capacity in Liters
Cardiac Risk Factors - Lipid profile 12 week Changes form the baseline, The lipid profile includes total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG). All units are in mmol/L.
Trial Locations
- Locations (1)
Pakistan Railway Hospital
🇵🇰Rawalpindi, Punjab, Pakistan