Personalised Prognostic Tools for Early Psychosis Management

• Conditions: Individuals in a clinically defined at-risk mental state for psychosishealthy volunteers; F20; F22; F23; F25; F28; F29; F32.3; F32; Other nonorganic psychotic disorders

• Registration Number: DRKS00005042
• Lead Sponsor: Department of Psychiatry and PsychotherapyLudwig-Maximilian-University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10-07
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 1680

Inclusion Criteria

Recent-onset psychosis (ROP):
•EITHER (i) transition criteria as defined by Yung et al. (1998)
•OR (ii) ICD-10: F20.x, F22.x, F23.x, F25.x, F28, F29, F31.2, F32.3

Recent-onset depression (ROD):
•ICD-10: F32.x

At-risk mental states for psychosis (ARMS):
•EITHER (i) CAARMS criteria
•OR (ii) SPI-A criteria
•OR (iii) GAF reduction = 30% and positive family history of psychoses
•OR (iv) GAF reduction = 30% and criteria for schizotypia (ICD-10: F21)

Controllgroup:
• healthy volunteers without a personal history of affective or non-affective psychoses or other psychiatric conditions and no family history of psychoses (1° relatives)

Exclusion Criteria

General exclusion:
•Age < 15 OR > 40
•IQ < 70
•Current or past head trauma
•Current or past neurological illness
•Current or past serious medical or surgical illness affecting CNS function
•ICD-10: Dependence syndrome (F1x.24 / F1x.25)

ROP:
•Duration of psychoses > 12 months
•Duration of antipsychotic medication > 3 months

ROD:
•Inclusion criteria for ROP and ARMS
•Duration of depressive episode > 12 months

ARMS:
Inclusion criteria for recent-onset psychoses

HC:
•Personal history of affective or non-affective psychoses or other psychiatric conditions
•Family history of psychoses (1° relatives)

Study & Design

• Study Type: observational
• Study Design: Not specified