Early and continuously raising of blood pressure may prevent fluctuations of cerebral blood flow in very low birth weight infants (VLBW) especially in VLBW infants without cerebral autoregulation!
Recruiting
- Conditions
- P07I95Disorders related to short gestation and low birth weight, not elsewhere classifiedHypotension
- Registration Number
- DRKS00013094
- Lead Sponsor
- Kinderklinik Heidelberg, Abteilung Neonatologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
preterm infant with a gestational age less than 30 weeks
Exclusion Criteria
heart failure
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean arterial blood pressure is observed in premature infants during the first 72 hours of life without and with hypotension therapy. If a central arterial catheter is indwelled, the arterial blood pressure is monitored continuously. Otherwise, non-invasive measurements are obtained using the oscillometric technique with an appropriate-sized cuff.
- Secondary Outcome Measures
Name Time Method During the first 72 hours of life the cerebral saturation is measured using near infrared spectroscopy, a non-invasive, continuous bedside measurement technique. The cerebral fractional tissue oxygen extraction can be calculated from this, which is an indirect measure of cerebral blood flow. In addition, the vital signs including blood pressure are recorded during routine monitoring. If a central arterial catheter is indwelled, the arterial blood pressure is monitored continuously. Otherwise, non-invasive measurements are obtained using the oscillometric technique. The mean arterial pressure and cerebral fractional tissue oxygen extraction are correlated. If there is cerebral autoregulation in premature infants, fluctuations of the MAP have no influence on the cerebral blood flow, i. e. there is no correlation.