DRKS00003721
Completed
Not Applicable
Identification of biomarkers sensitive to disease progression in patients with Mild Cognitive Impairment. Two-part Research: Part A - WP5P001 - Part A
ConditionsHealthy SubjectsMild Cognitive ImpairmentAlzheimer's disease / Alzheimer dementiaF00.0F00.1F00.2F00.9F06.7Dementia in Alzheimer disease with early onsetDementia in Alzheimer disease with late onsetDementia in Alzheimer disease, atypical or mixed typeDementia in Alzheimer disease, unspecifiedMild cognitive disorder
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy SubjectsMild Cognitive ImpairmentAlzheimer's disease / Alzheimer dementia
- Sponsor
- QUALISSIMA
- Enrollment
- 40
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Participants will be (i) healthy volunteers (between 50 and 80 years old) and/or (ii) subjects (between 50 and 80 years old), who will perform a 3T\-MRI for reasons such as migraine, headache, auditory or visual symptoms, paresthesias, and whose scan will be negative (see exclusion criteria below). Such subjects will be selected and asked to perform additional sequences according to the part A study protocol.
Exclusion Criteria
- •\-Ischaemic lesions already detected in a previous scan
- •\-Head injury with loss of consciousness \> 24 hours
- •\-Current substance abuse
- •\-Current therapy with steroids or current chemotherapy
- •\-Loss of weight \> 5 kg in the last 6 months
- •\-Systemic disease with frequent involvement of the CNS (lupus, HIV, rheumatoid arthritis)
- •\-CNS disease diagnosed by a specialist or in treatment (such as epilepsy, ictus)
- •\-Cerebral metastasis or CNS primary tumour still benign (except for pituitary microadenoma)
- •\-Suspected multiple sclerosis \+ MRI evidence of white matter lesions
- •\-Suspected recent stroke \+ MRI evidence of infarct
Outcomes
Primary Outcomes
Not specified
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