Effect of spironolactone versus placebo in patients with a hypertensive response to exercise
Phase 3
Completed
- Conditions
- Pre-hypertensionCardiovascular - Hypertension
- Registration Number
- ACTRN12609000835246
- Lead Sponsor
- niversity of Queensland
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Hypertensive response to exercise (HRE); maximum SBP/DBP (systolic/diastolic blood pressure) response to exercise >210/105 mmHg in men and >190/105 mmHg for women
Exclusion Criteria
1) hypertension at rest (>140/90 mmHg or on treatment for hypertension), 2) known coronary artery disease (angina, previous infarction, previous positive diagnostic test), 3) diabetes mellitus
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction of fibrosis, as assessed by backscatter and strain markers[Baseline vs 3 months following randomisation]
- Secondary Outcome Measures
Name Time Method Improvement in diastolic function using tissue Doppler echocardiography, measured as tissue diastolic velocity (e')[Baseline and 3 months following randomisation]