Prevention of osteoporosis in normogonadotropic anovulatory wome

Not Applicable

Completed

• Conditions: Osteoporosis; Musculoskeletal Diseases; Osteoporosis in diseases classified elsewhere

• Registration Number: ISRCTN55207514
• Lead Sponsor: The Chinese University of Hong Kong (Hong Kong)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-08-31
• Last Update Posted: 27 February 2017

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

1. Women aged 20-45 years
2. Either 12 months of amenorrhoea or a menstrual cycle of average length 35 days or longer in the previous 12 months
3. At baseline Follicle-stimulating hormone (FSH) > 3.5 IU/L, < 10 IU/L
4. Luteinizing hormone (LH) > 2.4 IU/L, < 12.6 IU/L
5. E2 < 201 pmol/L
6. PRL < 496 mIU/

Exclusion Criteria

1. On exogenous hormones within previous 3 months
2. Any contraindication to the use of female hormones
3. Any condition making it likely that they cannot complete the study
4. Hypergonadotropic or hypogonadotropic hypogonadism or hyperprolactinaemia as defined by abnormal FSH, LH or Prolactin concentrations
5. Any personal or strong family history of breast cancer or endometrial cancer
6. History of pulmonary or venous thromboembolism

Study & Design

• Study Type: Interventional
• Study Design: Not specified