A pilot study to compare the effect of oestrogen combined with a progestogen in the form of either an oral contraceptive (OC) or hormone replacement therapy (HRT) on bone mineral density (BMD) in normogonadotropic hypoestrogenic anovulatory women

The Chinese University of Hong Kong (Hong Kong)0 个研究点目标入组 100 人开始时间: 2012年8月31日最近更新: 2017年2月27日

适应症

试验速览

暂无简介。

•1. Women aged 20-45 years
•2. Either 12 months of amenorrhoea or a menstrual cycle of average length 35 days or longer in the previous 12 months
•3. At baseline Follicle-stimulating hormone (FSH) > 3.5 IU/L, < 10 IU/L
•4. Luteinizing hormone (LH) > 2.4 IU/L, < 12.6 IU/L
•5. E2 < 201 pmol/L
•6. PRL < 496 mIU/

•1. On exogenous hormones within previous 3 months
•2. Any contraindication to the use of female hormones
•3. Any condition making it likely that they cannot complete the study
•4. Hypergonadotropic or hypogonadotropic hypogonadism or hyperprolactinaemia as defined by abnormal FSH, LH or Prolactin concentrations
•5. Any personal or strong family history of breast cancer or endometrial cancer
•6. History of pulmonary or venous thromboembolism

发起方