DYNAMIC STRESS PERFUSION CT FOR DETECTION OF INDUCIBLE MYOCARDIAL ISCHEMIA
- Conditions
- due to functional constriction or actual obstruction of a blood vessel.MYOCARDIAL ISCHEMIAdeficiency of blood in a part10011082
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 70
* Age > 21 years
* Stable angina symptoms, suspected or known CAD, and referred for invasive angiography on clinical grounds.
* Ability to provide informed consent
* Ability to perform a 20-30 second breath hold
* Hemodynamically and clinically unstable condition (angina at rest, malignant arrhythmias)
* Prior, documented myocardial infarction, other than (procedure related) minor type II myocardial infarction, which includes Q waves on the ECG or evidence of myocardial infarction on prior non-invasive imaging.
* Coronary artery bypass graft surgery or primary PCI for acute myocardial infarction.
* Significant other cardiovascular conditions affecting the interpretation of MPICT, including, but not limited to: clinical heart failure, IECD (pacemaker/ICD), severe valvular heart disease or prosthetic valves, significant intra-cardiac shunting or other relevant congenital heart disease.
* eGFR<60 ml/kg/min
* BMI>35 kg/m2
* Atrial fibrillation or other arrhythmia, >6 ectopic beats / min
* Known or suspected allergy to iodinated contrast medium
* Pregnancy cannot be excluded
* Contra-indications for adenosine: bronchial asthma, second or third degree atrioventricular block, blood pressure <110/70 mmHg, allergies or severe side effects in the past.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Myocardial perfusion defect on dynamic CT perfusion imaging, and diagnostic<br /><br>accuracy as compared invasive FFR.</p><br>
- Secondary Outcome Measures
Name Time Method <p>na</p><br>