Cranial Nerve Functions in Behçet's Disease and Their Relationship With Clinical Parameters

Not yet recruiting

• Conditions: Behcet Disease; Cranial Nerve Disorder

• Registration Number: NCT07135063
• Lead Sponsor: Marmara University

Brief Summary

The goal of this study is to find out whether cranial nerves are affected in people with Behçet's Disease (BD), and how this might relate to other disease features. Cranial nerves control important functions such as vision, facial movement, hearing, swallowing, and balance.

The main questions this study will address are:

* Do people with BD have changes in cranial nerve function compared to healthy individuals?

* Are these changes linked to disease duration, symptoms, or lab results?

Participants will:

* Answer questions about their medical history and BD symptoms

* Complete questionnaires on daily function, mood, and autonomic symptoms

* Have a clinical examination of all 12 cranial nerves

* Undergo non-invasive electrical tests to assess nerve function This study will not involve any medications. All procedures will be completed in one visit.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-07-22
• Status Verified: 2025-08
• Study First Submitted QC: 2025-08-13
• Last Update Submitted: 2025-08-13
• Study First Posted: 2025-08-21
• Last Update Posted: 2025-08-21
• Study Start: 2025-10-01
• Primary Completion: 2026-01
• Study Completion: 2026-09-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Aged 18-75
• Diagnosed with BD according to ACR/EULAR 2013 criteria (patient group)
• Healthy with no relevant medical history (control group)

Exclusion Criteria

• Conditions affecting CN assessment (e.g., facial trauma, surgery, radiotherapy)
• Other rheumatologic or autoimmune diseases
• Psychiatric disorders, alcohol/substance abuse
• Pregnant women
• Use of pacemakers or recent botox to masseter muscle

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Establish the presence or absence of cranial nerve involvement in BD.	Once: Upon patient inclusion	Upon patient inclusion EMG and clinical examination is carried out

Secondary Outcome Measures

Name	Time	Method
Investigate relation between disease duration (months) and cranial nerve involvement in BD patients	Once: Upon patient inclusion

Trial Locations

Locations (1)

Marmara Üniversitesi Tıp Fakültesi; 🇹🇷 Istanbul, Maltepe, Turkey