Intra-Abdominal Instillation Of Fresh Frozen Plasma Versus Corticosteroids In Prevention Of Recurrent Attacks Of Adhesive Intestinal Obstruction: A 2 Years' Experience Clinical Study

Not Applicable

Not yet recruiting

• Conditions: Adhesive Peritoneal Band

• Registration Number: NCT06859307
• Lead Sponsor: Zagazig University

Brief Summary

Adhesive Intestinal obstruction is an inevitable complication of abdominal surgery with significant morbidity associated with poor quality of life and predispose to repeated hospitalization. Most of them (73% - 90%) can be managed conservatively.Despite advances in surgery, 15to 30% require surgical intervention primarily or due to failure of conservative management. Because of the nature of the disease recurrence has been estimated to be 30%.Many attempts to prevent formation of postoperative adhesions have been tried. In this trial, we will study the effect of corticosteroids and FFP in prevention of adhesive small bowel obstruction recurrence for follow up of 2 years duration.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-02
• Study First Submitted: 2025-02-27
• Study First Submitted QC: 2025-02-27
• Last Update Submitted: 2025-02-27
• Study Start: 2025-03-01
• Study First Posted: 2025-03-05
• Last Update Posted: 2025-03-05
• Primary Completion: 2027-03-01
• Study Completion: 2027-03-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 176

Inclusion Criteria

• Patients with attacks of adhesive intestinal obstruction

Exclusion Criteria

• Associated abdominal malignancy, patients with adhesive IO who respond to conservative treatment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
intestinal obstruction	from 1 day to 2 years post operative	intestinal obstruction is detected if the patient had constipation and vomiting with ultrasound showing dilated bowel and to and fro movement and the plain erect shows multiple air fluid levels
bowel injury	from 1 day to 2 years post operative	bowel injury will be detected if intestinal contents present in the drain or wound
wound infection	from 1 day to 2 weeks post-operative	wound infection is detected if there is pus in the drain or wound

Secondary Outcome Measures

Name	Time	Method
age	from 2 to 3 days before surgery	age will be recorded in years
sex	from 2 to 3 days before surgery	The sex of the patient will be recorded (male or female)

Trial Locations

Locations (2)

Faculty of Medicine; 🇪🇬 Zagazig, Sharqia, Egypt

Zagazig University Hospitals; 🇪🇬 Zagazig, Egypt