Optical spectral transmission imaging for treatment monitoring and correlation with arterial stiffness in patients with rheumatoid artritis starting with TNF inhibiting therapy

Completed

• Conditions: inflammatory arthritis; rheumatoid arthritis; 10023213

• Registration Number: NL-OMON48787
• Lead Sponsor: Reade

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-07-12
• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 62

Inclusion Criteria

Rheumatoid arthritis group
- 18 years or older
- Active rheumatoid arthritis in hands or wrists, defined as * 2 swollen hand joints (IP, PIPs and/or MCPs) or * 1 swollen wrist joints;Hypertension group
- 18 years or older
- Patients with hypertension, defined as systolic blood pressure >140 mmHg and/or diastolic blood pressure >90 mmHg or currently on antihypertensive treatment
- No rheumatoid arthritis;Healthy controls group
- 18 years or older
- No hypertension, defined as systolic blood pressure *140 mmHg, diastolic bloodpressure * 90 mmHg and no antihypertensive treatment
- No rheumatoid arthritis

Exclusion Criteria

- Surgery in wrist or hand in the preceding 3 months
- Other active concomitant musculoskeletal disease

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the results from the handscan measurement,<br /><br>arterial stiffness as measured with pulse wave velocity and augmentation index,<br /><br>DAS28 and the ultrasound assessment of the hand joints at all time points<br /><br>(baseline, 1 month and 4 months).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n/a</p><br>