Fetal Magnetic Resonance Imaging: Z-score Reference Ranges for a Large Patient Population in Normal Neuroimaging Measurement

• Conditions: Fetal Growth Retardation; Fetal Neurodevelopmental Disorder

• Registration Number: NCT07004283
• Lead Sponsor: Guangzhou Women and Children's Medical Center

Brief Summary

This study aims to establish the z score reference ranges of fetal head circumference and other measurement of fetal measurements including biparietal diameter, fronto-occipital diameter, length of the corpus callosum, lateral ventricle, transverse cerebellar diameter, height of the vermis, anteroposterior diameter of the vermis，height and width of normal fetuses from 18 to 40 weeks' gestation.

Method-A cohort-based study was conducted on low-risk singleton pregnancies with healthy fetuses. The measurement was performed using simple 2-dimensional MRI on the typical fetal standard view. The reference ranges were constructed according to gestational age (GA), biparietal diameter (BPD), as independent variables based on the best-fit models, both mean and standard deviation (SD).

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-01
• Status Verified: 2025-05
• Study First Submitted: 2025-05-27
• Study First Submitted QC: 2025-05-27
• Last Update Submitted: 2025-05-27
• Study First Posted: 2025-06-04
• Last Update Posted: 2025-06-04
• Primary Completion: 2029-12-30
• Study Completion: 2030-12-30

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: Female
• Target Recruitment: 800

Inclusion Criteria

• The pregnant women in Born in Guangzhou Cohort Study

Exclusion Criteria

• The fetuses with prenatal diagnosis of congenital heart disease or other congenital diseases.

The fetuses who are high-risk neonates at the delivery.1) preterm infants; (2) infants with extremely low birth weight (ELBW) or who are small for gestational age (SGA);

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Birth	20 weeks follow up	Healthy birth

Secondary Outcome Measures

Name	Time	Method
low birth weight	20 weeks follow up	Healthy birth

Trial Locations

Locations (1)

Siemens Skyra 3.0T MRI; 🇨🇳 Guangzhou, Guangdong, China