Impact of tissue specific isoflavone profiles on the formation, activation, and action of 17ß-estradiol in the female mammary gland
- Conditions
- estradiol homeostasis and associated effects in breast tissue
- Registration Number
- DRKS00000598
- Lead Sponsor
- ehrstuhl für Lebensmittelchemie, Institut für Pharmazie und Lebensmittelchemie, Universität Würzburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 60
Inclusion Criteria
cosmetically motivated breast reduction surgery
Exclusion Criteria
Pathological changes in the breast tissue, family history of breast cancer, soy allergy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Endpoint: biotransformation of estradiol and isoflavonen in the mammary gland.<br>Time point: 1 day after last application. <br>Method: GC- and LC/MS/MS.
- Secondary Outcome Measures
Name Time Method Endpoints: cellular response zu altered estradiol biotransformation (genotoxicity, cell proliferation and differentiation in the mammary gland).<br>Time point: 1 day after the las application.<br>Method: real-time PCR, immunohistology.