Volumetric Bone Mineral Density and it's Relationship With Osteoporotic Fractures in Parkinson's Disease

Not Applicable

Completed

• Conditions: Idiopathic Parkinson's Disease
• Interventions: Other: High resolution peripheral scanner (HRpQCT).

• Registration Number: NCT03095690
• Lead Sponsor: Centre Hospitalier Régional d'Orléans

Brief Summary

Idiopathic Parkinson's disease (IPD) is the second most frequent neurodegenerative disease. Its association with osteroporosis and fragility fracture is now clearly demonstrated, but the determinants of this osteoporosis are yet to be explained. Our aim was to study factors associated with volumetric bone mineral density (vBMD) and bone microstructure at the tibia and radius in IPD.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-07
• Primary Completion: 2016-07
• Study First Submitted: 2017-02-08
• Study First Submitted QC: 2017-03-24
• Study First Posted: 2017-03-30
• Study Completion: 2017-06-21
• Status Verified: 2018-03
• Last Update Submitted: 2018-03-12
• Last Update Posted: 2018-03-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Patients with idiopathic Parkinson's disease according to the criteria of the UKPDBB.
• Parkinson's disease of moderate severity (Index HOEHN and Yahr <5)
• Patient can respond to questionnaires, with or without help

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Exclusion Criteria

• Patients with active psychiatric illness preventing the realization of examinations
• Severe Parkinson's disease (Index HOEHN and Yahr ≥5 )
• Heavy-morbidity including heart failure NYHA> 3 or chronic respiratory failure, terminal or severe renal impairment known dialyzed
• Pregnancy

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Idiopathic Parkinson's Disease patients	High resolution peripheral scanner (HRpQCT).	High resolution peripheral scanner (HRpQCT).

Primary Outcome Measures

Name	Time	Method
Measurement of volumetric bone mineral density at the tibia and radius	0 hour	Measurement performed by High Resolution peripheral Quantitative Computed Tomography (HRpQCT)

Trial Locations

Locations (1)

CHR d'ORLEANS; 🇫🇷 Orleans, France