Bone Mineral Density in Tremor Dominant Type Compared to Postural Instability Gait Difficulty Type Parkinson's Disease: a Cross-sectional Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Dual-energy X-ray absorptiometry (DEXA)
研究概览
简要总结
The bone loss in Parkinson's disease (PD) emerges as a non-motor symptom with motor and non-motor outcomes, such as fracture and musculoskeletal pain. Bone mineral density (BMD) is decreasing in patients with PD when compared to sex and age-matched healthy controls. The changes in BMD according to clinical subtypes of PD is unknown. The investigators are planning to compare the BMD status between the tremor dominant and postural instability and gait difficulty type of PD.
详细描述
The investigators are planning to complete this study between January and February 2019. This study will be performed at Ordu University Education and Research Hospital, Neurology Department.
All patients admitted to the outpatient clinic will be evaluated in terms of inclusion criteria. The control group consisted of people who do not have any orthopedic, neurological or metabolic disorders which may affect the BMD.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of idiopathic Parkinson's disease Age of 40-85 years
排除标准
- •Having additional orthopedic and neurological disorders Having metabolic disease, Having steroid drug use
- •For Control group
- •The similar age and sex-matched healthy individuals who have no orthopedic, metabolic and neurological disorders, and steroid use will be included in the study.
结局指标
主要结局
Dual-energy X-ray absorptiometry (DEXA)
时间窗: 10-15 minutes
Bone mineral density will be dertermined using DEXA results. The results will be interpreted by WHO (World Health Organization) criteria. : T-score (T-score) is determined by DEXA method. A T-score value of more than minus means that there is excess bone loss. * Obsolete osteoporosis: A T-score of less than -2.5 SD and a history of fracture in a patient. * Osteoporosis: T-score below -2.5 SD. (Like -3, -4 ...) * Osteopenia: T-score between -1 and -2.5 SD * Normal: T-score value better than -1
次要结局
- Unified Parkinson's Disease Rating Scale (UPDRS) - Motor Section(10 minutes)
- Unified Parkinson's Disease Rating Scale (UPDRS) - non-motor Section(5 minutes)
- Hoehn and Yahr Scale(2 minutes)
- Unified Parkinson's Disease Rating Scale (UPDRS) - Section of Activities of Daily Living (ADL)(10 minutes)
- Unified Parkinson's Disease Rating Scale (UPDRS) - complications Section(5 minutes)
研究者
Sevim ACARÖZ CANDAN
Head of Department of Physiotherapy and Rehabilitation
T.C. ORDU ÜNİVERSİTESİ