Comparing therapeutic efficacy of N-acetyl cysteine with the combination of N-acetyl cysteine and Cimetidine in acute acetaminophen toxicity
Phase 2
- Conditions
- Acute acetaminophen toxicity.Poisoning by drugs, medicaments and biological substancesT36, T37,
- Registration Number
- IRCT2013102915204N1
- Lead Sponsor
- Vice chancellor for research, Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
The inclusion major criteria to study, are: having para-clinical acetaminophen toxicity (toxic acetaminophen serum levels), and referring to the emergency poisoning department of Imam Reza Hospital, less than 8 hours from the poisoning.
Exclusion major criteria from study, are as follows: having multiple toxicities; simultaneous diseases affecting the liver enzymes (e.g. heart failure, congenital liver defects, and hepatitis); recent (less than a week) or regular consumption of other drugs;Those patients who didn’t consent to the treatment, or were discharged from the hospital, were also excluded from the study.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum level of acetaminophen. Timepoint: admission-next morning- discharging. Method of measurement: blood Sampling.
- Secondary Outcome Measures
Name Time Method Serum level of Serum aminotransferases. Timepoint: admission-next morning- discharging. Method of measurement: blood Sampling.