The effect of acetaminophen on ischemia- reperfusion injery in patients with ST segment elevation acute myocardial infarction treated by primary percutaneous coronary interventio
Not Applicable
- Conditions
- ST segment elevation acute myocardial infarction.Acute myocardial infarction
- Registration Number
- IRCT2017011828454N3
- Lead Sponsor
- Vice Chancellor for Research and Technology, Kermanshah University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Inclusion criteria include: patient willingness to take part in the study, informed consent, age above 20 and below 65 years and include all patients with STEMI.
Exclusion criteria included a history of kidney and liver disease, acute hepatitis, asthma, pregnancy, cardiac output less than 30%, history of heart failure, and consumption of acetaminophen, warfarin, salicylates, barbiturates, carbamazepine, hydantoin and rifampin, rifabutin, isoniazid, alcohol, and antioxidants drugs.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Homocysteine. Timepoint: Before and after primaryprecutanous coronary intervention. Method of measurement: Measuring the level of homocysteine in coronary blood sample.;Glutathione. Timepoint: Before and after primaryprecutanous coronary intervention. Method of measurement: Measuring the level of Glutathionein coronary blood sample.;Malondialdehyde. Timepoint: Before and after primaryprecutanous coronary intervention. Method of measurement: Measuring the level of malondialdehydecoronary blood sample.
- Secondary Outcome Measures
Name Time Method DH. Timepoint: Before and six hours after primary precutaneous coronary intervention. Method of measurement: Measuring the level of LDH from peripheral blood serum.;Troponine. Timepoint: Before and six hours after primary precutaneous coronary intervention. Method of measurement: Measuring the level of troponinefrom peripheral blood serum.;CPK-mb. Timepoint: Before and six hours after primary precutaneous coronary intervention. Method of measurement: Measuring the level of CPK-mb from peripheral blood serum.;CPK. Timepoint: Before and six hours after primary precutaneous coronary intervention. Method of measurement: Measuring the level of CPK from peripheral blood serum.