The Effect of Aerobic Training on Total Antioxidant Status, Total Oxidant Status, Glutathione, Oxidative Glutathione and Zonulin Levels in Patients With Parkinson's Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Glutathione
研究概览
简要总结
Parkinson's disease is a chronic, neurodegenerative disorder characterized with the loss of dopamine-producing neurons. This loss is likely to be related with several environmental and genetic factors. One of the most important factor that is responsible for the initation and progression of the disease is oxidative stress. Exercise training, especially aerobic training, can change the levels of oxidative markers because exercise can lead to decrease oxidative stress in patients with Parkinson's disease. Therefore, this study aims to investigate (1) the effect of aerobic training on total antioxidant status, total oxidant status, glutathione, oxidative glutathione, and zonulin levels, (2) the relationship between the change of motor symptoms and disease severity and the change of total antioxidant status, total oxidant status, glutathione, oxidative glutathione, and zonulin levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •at least 40years of age
- •diagnosed with Parkinson's Disease
- •Hoehn and Yahr stage of 1 and 3
排除标准
- •any other neurologic disorders,
- •any cardiovascular, orthopedic, vestibular or rheumatic conditions that impact exercise training
- •visual, auditory, and perception problems.
结局指标
主要结局
Glutathione
时间窗: 10 minutes
Glutathione is an important intracellular antioxidant that protects against a variety of different antioxidant species.
Total antioxidant status
时间窗: 10 minutes
Total antioxidant status is an important marker of total antioxidant capacity and it indicates an overall measure for the cumulative action of all antioxidants.
Oxidative glutathione
时间窗: 10 minutes
Oxidative glutathione generated by glutathione reductase should be provided as decreased glutathione to the site.
Total oxidant status
时间窗: 10 minutes
Total oxidant status is an significant marker of total oxidant capacity and it indicates an overall measure for the cumulative action of all oxidants.
Zonulin
时间窗: 10 minutes
The levels of zonulin can reflect systemic inflammation and oxidative stress.
次要结局
- Movement Disorders Society Unified Parkinson's Disease Rating Scale(15 minutes)
研究者
Fatih Söke
Assistant Professor
Saglik Bilimleri Universitesi