Effect of Aerobic Training on Oxidative Stress Markers in Patients With Parkinson's Disease

Not Applicable

• Conditions: Parkinson Disease
• Interventions: Other: Exercise training

• Registration Number: NCT05511402
• Lead Sponsor: Saglik Bilimleri Universitesi

Brief Summary

Parkinson's disease is a chronic, neurodegenerative disorder characterized with the loss of dopamine-producing neurons. This loss is likely to be related with several environmental and genetic factors. One of the most important factor that is responsible for the initation and progression of the disease is oxidative stress. Exercise training, especially aerobic training, can change the levels of oxidative markers because exercise can lead to decrease oxidative stress in patients with Parkinson's disease. Therefore, this study aims to investigate (1) the effect of aerobic training on total antioxidant status, total oxidant status, glutathione, oxidative glutathione, and zonulin levels, (2) the relationship between the change of motor symptoms and disease severity and the change of total antioxidant status, total oxidant status, glutathione, oxidative glutathione, and zonulin levels.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-08
• Study First Submitted: 2022-08-19
• Study First Submitted QC: 2022-08-19
• Last Update Submitted: 2022-08-22
• Study First Posted: 2022-08-23
• Study Start: 2022-08-25
• Last Update Posted: 2022-08-25
• Primary Completion: 2022-11-30
• Study Completion: 2022-12-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• at least 40years of age
• diagnosed with Parkinson's Disease
• Hoehn and Yahr stage of 1 and 3

Exclusion Criteria

• any other neurologic disorders,
• any cardiovascular, orthopedic, vestibular or rheumatic conditions that impact exercise training
• visual, auditory, and perception problems.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Conventional physiotherapy	Exercise training	This group will participate in a conventional physiotherapy program (8-week, 3 times weekly, and 45-min each time).
Aerobic exercise	Exercise training	This group will participate in an aerobic training program (8-week, 3 times weekly, and 30-min each time) and conventional physiotherapy program (8-week, 3 times weekly, and 45-min each time).

Primary Outcome Measures

Name	Time	Method
Glutathione	10 minutes	Glutathione is an important intracellular antioxidant that protects against a variety of different antioxidant species.
Total antioxidant status	10 minutes	Total antioxidant status is an important marker of total antioxidant capacity and it indicates an overall measure for the cumulative action of all antioxidants.
Oxidative glutathione	10 minutes	Oxidative glutathione generated by glutathione reductase should be provided as decreased glutathione to the site.
Total oxidant status	10 minutes	Total oxidant status is an significant marker of total oxidant capacity and it indicates an overall measure for the cumulative action of all oxidants.
Zonulin	10 minutes	The levels of zonulin can reflect systemic inflammation and oxidative stress.

Secondary Outcome Measures

Name	Time	Method
Movement Disorders Society Unified Parkinson's Disease Rating Scale	15 minutes	The Movement Disorders Society Unified Parkinson's Disease Rating Scale is the most commonly used scale to assess disease severity in Parkinson's Disease. It consists of four parts: (1) non-motor experiences of daily living, (2) motor experiences of daily living, (3) motor examination, and (4) motor complications.

Trial Locations

Locations (1)

Saglik Bilimleri Universitesi; 🇹🇷 Ankara, Turkey