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临床试验/NCT02503007
NCT02503007已完成不适用

The Effects of 14-days of HMB-Free Acid on Changes in Muscle Architecture, Blood Markers of Muscle Damage and Performance During 4-Days of Survival Training

Metabolic Technologies Inc.1 个研究点 分布在 1 个国家目标入组 27 人开始时间: 2015年7月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
27
试验地点
1
主要终点
Muscle Strength

研究概览

简要总结

Sustained high-intensity activity, such as survival training with little nourishment available, can result in a loss of muscle performance. This study will examine the effects of a nutritional supplement to maintain muscle and muscle performance during this period.

详细描述

Sustained high intensity activity that is often accompanied by sleep and nutrient deprivation is a common characteristic of survival training. Survival training is a requirement in the preparation of pilots, where they learn evasion and survival skills that they may need to avoid capture in a situation in which they have bailed from their plane. The physiological stresses associated with the nature of these operations often results in significant decrements in lean body mass, muscle size and muscle endurance and power. During a sudden evacuation from the aircraft the pilot only takes a small survival bag. There is a limit to what can possibly be put in this bag. However, the ability to provide a dietary supplement specifically targeting muscle may provide an important resource for maintaining muscle mass and performance. Thus, the purpose of this study is to determine the efficacy of 14 days of HMB-FA ingestion on maintaining muscle architecture and muscle performance during 4-days of survival training. In addition, anabolic and catabolic markers of stress, inflammation and muscle damage will be assessed.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
Triple (Participant, Care Provider, Investigator)

入排标准

年龄范围
18 Years 至 27 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • 18 to 27 Years of age
  • Soldier members of Special Operations
  • Healthy as assessed by the Unit's Medical Officers
  • Subject provides written and dated informed consent to participate

排除标准

  • A history of medical or surgical events that may significantly affect the study outcome, including cardiovascular disease, metabolic, renal, hepatic, or musculoskeletal disorders
  • Use of medications that may affect the study outcomes
  • Use of nutritional supplements (such as protein drinks, creatine, HMB and vitamins) in the 3 months prior to the start of the study
  • Subject is currently participating in another clinical trial or has received an investigational product within thirty days prior to screening/enrollment

结局指标

主要结局

Muscle Strength

时间窗: Day 18

Hand grip strength will be measured using a hand-grip dynamometer.

次要结局

  • Muscle Power(Day 18)
  • Muscle Morphology(Day 18)
  • Muscle Mass(Day 18)
  • Urine Biochemical Analysis(Day 18)
  • Blood Biochemical Analysis(Day 18)

研究者

申办方类型
Industry
责任方
Sponsor

研究点 (1)

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