Relationship Between Erythropoietin Administration and Stress Responses in Trauma Patients

Phase 2

• Conditions: Multiple Trauma
• Interventions: Drug: placebo; Drug: erythropoietin

• Registration Number: NCT00622934
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

The purpose of this study is to determine whether Erythropoietin decrease stress responses and inflammation in trauma patient.

Detailed Description

Transfusion of blood products has many disadvantages. Erythropoietin is used to increase red blood cells production and decrease such disadvantages.In some studies anti inflammatory effects is shown for Erythropoietin.

One of the most problems in the intensive care unit is stress response. we are going to evaluate effects of erythropoietin on oxidative stress and inflammation in trauma patient in intensive care unit.

Study Timeline

• Study Start: 2007-07
• Study First Submitted: 2008-02-13
• Study First Submitted QC: 2008-02-21
• Study First Posted: 2008-02-25
• Primary Completion: 2008-05
• Study Completion: 2008-05
• Status Verified: 2010-11
• Last Update Submitted: 2010-11-17
• Last Update Posted: 2010-11-18

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• All multiple trauma patients>16 years with informed consent

Exclusion Criteria

• Hypertension
• Allergy
• Erythroid leukemia
• Pregnancy and breast feeding
• Pre operative patient
• Severe cardiovascular and cerebrovascular diseases
• Thromboembolic disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
2	placebo	-
1	erythropoietin	-

Primary Outcome Measures

Name	Time	Method
apachi 2 saps 30 days mortality	untill discharge

Secondary Outcome Measures

Name	Time	Method
30 days mortality	30 days

Trial Locations

Locations (1)

Sina Hospital; 🇮🇷 Tehran, Iran, Islamic Republic of