Blood Pressure or Cardiac Output - the Influence on Cerebral Perfusion During Cardiopulmonary Bypass
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- UMC Utrecht
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- regional cerebral oxygen saturation
研究概览
简要总结
The purpose of this study is to determine whether cerebral blood flow and cerebral tissue oxygenation is most dependent on cardiac output or on mean arterial pressure in patients undergoing cardiac surgery with the use of cardiopulmonary bypass.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Undergoing cardiopulmonary bypass for CABG a
- •having an appropriate temporal bone window for reliable TCD monitoring
- •needing pharmacological intervention because of hypotension before going on CPB.
排除标准
- •requiring hypothermia during surgery
- •requiring emergency surgery
- •contraindication for phenylephrine,
- •having known brain pathology (e.g. Cerebral Vascular Accident (CVA) or increased intracranial pressure
- •having a history of severe carotid artery stenosis.
研究组 & 干预措施
Patient for cardiac surgery
All patient undergo the 5 different intervention in a randomised matter.
干预措施: Increasing CPB flow (Other)
Patient for cardiac surgery
All patient undergo the 5 different intervention in a randomised matter.
干预措施: Decreasing CPB flow AND 50-100ug phenylephrine (Other)
Patient for cardiac surgery
All patient undergo the 5 different intervention in a randomised matter.
干预措施: decreasing CPB flow (Other)
Patient for cardiac surgery
All patient undergo the 5 different intervention in a randomised matter.
干预措施: 50-100ug phenylephrine before CPB (Other)
Patient for cardiac surgery
All patient undergo the 5 different intervention in a randomised matter.
干预措施: 50-100ug phenylephrine during CPB (Other)
结局指标
主要结局
regional cerebral oxygen saturation
时间窗: During surgery
mean velocity of blood flow of the middle cerebral artery
时间窗: During surgery
次要结局
未报告次要终点