Laryngeal Injuries After Removal of the Tracheal Tube: A Comparison Between Anesthesia With Sevoflurane and Intravenous Anesthesia With Propofol A Randomized, Prospective, Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Sevoflurane
- Conditions
- Vocal Cord; Injury, Superficial
- Sponsor
- University of Rostock
- Enrollment
- 65
- Locations
- 1
- Primary Endpoint
- incidence of vocal cord injuries
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
Vocal cord injuries occur not only during tracheal intubation, but also during surgery and during removal of tracheal tube. Volatile anesthetics increase neuromuscular block of muscle relaxants. Thus, the investigators tested the hypothesis, that sevoflurane would cause less vocal cord injuries than a total intravenous anesthesia with propofol.
Detailed Description
Volatile anaesthetics increase neuromuscular block of neuromuscular blocking drugs. We tested the hypothesis, that sevoflurane would cause less vocal cord injuries than an intravenous anaesthesia with propofol. Sixty five patients were randomly assigned to the SEVO group (anaesthesia with sevoflurane) or TIVA group (anaesthesia with propofol). Vocal cord injuries were examined by stroboscopy before and 24 and 72 h after surgery; hoarseness was assessed up to 72 h.
Investigators
Thomas Mencke
Thomas Mencke
University of Rostock
Eligibility Criteria
Inclusion Criteria
- •orotracheal intubation
- •surgery of the ear
- •written consent
- •ASA I-III
Exclusion Criteria
- •preexisting pathologies of the vocal cords
- •difficult airway
Arms & Interventions
Sevoflurane
Anesthesia was maintained with sevoflurane during surgery.
Intervention: Sevoflurane
Anesthesia with propofol
Anesthesia was maintained with propofol during surgery.
Intervention: propofol
Outcomes
Primary Outcomes
incidence of vocal cord injuries
Time Frame: 24h after surgery
assessed by stroboscopy
Secondary Outcomes
- incidence of hoarseness(24h after surgery)