Laryngeal Injuries After Anesthesia Induction With Three Different Sevoflurane Concentrations (Without Muscle Relaxant)
Overview
- Phase
- Not Applicable
- Intervention
- sevoflurane 1,0
- Conditions
- Other Specified Injuries of Vocal Cord, Sequela
- Sponsor
- University of Rostock
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- incidence of vocal cord injuries
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Anesthesia induction and tracheal intubation can be performed with and without neuromuscular blocking agents (NMBAs). Tracheal intubation can be performed with sevoflurane instead of NMBAs; intubating conditions are similar and the incidence of vocal cord injuries are similar, too.
Detailed Description
We perform tracheal intubation with propofol, remifentanil and sevoflurane; sevoflurane is administered with three dosages. During tracheal intubation intubating conditions are noted. After surgery, all patients are examined by video laryngoscopy; moreover all patients are asked for hoarseness and sore throat.
Investigators
Thomas Mencke
Clinical Associate Professor Dr Thomas Mencke
University of Rostock
Eligibility Criteria
Inclusion Criteria
- •ear-nose-throat surgery
- •orotracheal intubation for surgery of the ear
- •ASA I-III
Exclusion Criteria
- •allergy against the study drugs
- •patients with a known or suspected difficult airway
- •diseases of the larynx
Arms & Interventions
sevoflurane 1,0
sevoflurane 1,0: sevoflurane is administered with a concentration of 1,0 MAC
Intervention: sevoflurane 1,0
sevoflurane 1,2
sevoflurane 1,2: sevoflurane is administered with a concentration of 1,2 MAC
Intervention: sevoflurane 1,2
sevoflurane 1,4
sevoflurane 1,4: sevoflurane is administered with a concentration of 1,4 MAC
Intervention: sevoflurane 1,4
Outcomes
Primary Outcomes
incidence of vocal cord injuries
Time Frame: 24 hours after tracheal intubation
Secondary Outcomes
- incidence of soar throat(24, 48, and 72 hours after tracheal intubation)
- incidence of hoarseness(24, 48, and 72 hours after tracheal intubation)