The Effects of Cardiorespiratory Fitness, Physical Activity and Sedentary Behavior on Insulin Resistance Among Breast Cancer Survivors Being Treated With Anti-estrogen Endocrine Therapies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Insulin Resistance
研究概览
简要总结
The aim of this study is to learn more about how physical activity and cardiorespiratory fitness are related to diabetes risk among breast cancer patients prescribed an endocrine therapy.
详细描述
80 women between the ages of 18-80 years will be recruited for this study. The study design consists of two separate in-person visits to University of Colorado Anschutz Medical Campus or Colorado State University. The study consists of glucose testing, a body composition scan, exercise testing, and a two-week period of free living activity monitoring.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •diagnosed with breast cancer
- •age 18-80 years
- •Completed surgery, chemo- and/or radiation therapy
- •Prescribed aromatase inhibitor or SERM for at least one year from the time of screening
排除标准
- •Age < 18 or > 80
- •Type 1 diabetes
- •Type 2 diabetes
- •Prescribed anti-hyperglycemic medication, insulin, or sulfonylurea.
- •Pregnant, breastfeeding or planning to become pregnant in next 2 months
- •Have absolute contraindications to exercise testing which are:
- •Unstable angina
- •Recent myocardial infarction, cardiac surgery, or vascular surgery (<3 months)
- •Uncontrolled high blood pressure
- •Heart failure
- •Peripheral artery disease (based on report of symptomatic claudication)
- •Hepatic or renal disease
- •Severe arthritis or mobility impairment that would interfere with exercise testing
- •Suspected cognitive impairment that would prevent understanding or comprehension of study procedures.
研究组 & 干预措施
SERM
These patients are being treated with a SERM for at least one year prior to enrolling in the study.
干预措施: No intervention (Other)
Aromatase Inhibitor
These patients are being treated with an aromatase inhibitor for at least one year prior to enrolling in the study.
干预措施: No intervention (Other)
结局指标
主要结局
Insulin Resistance
时间窗: Immediately after the consent form is signed
Insulin resistance will be measured through oral glucose tolerance testing
Body Composition
时间窗: Immediately after the insulin resistance measurement
Body composition will be measured through DEXA scan
Maximal Exercise Capacity
时间窗: Within 2-60 days of insulin resistance measurement
Maximal exercise capacity measured through graded exercise test on stationary bicycle
Daily Activity
时间窗: 2-60 days following insulin resistance measurement
Daily activity measured using activity monitor
次要结局
未报告次要终点