Acute effects of nitrate-rich spinach on arterial stiffness in healthy men and wome

Not Applicable

Completed

• Conditions: Blood pressure; Vascular function; Cardiovascular - Hypertension; Diet and Nutrition - Other diet and nutrition disorders; Public Health - Other public health

• Registration Number: ACTRN12612000643875
• Lead Sponsor: niversity of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-06-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Healthy men and women

Exclusion Criteria

current smoking;
BMI <18 or >35 kg/m2;
systolic blood pressure (SBP) <110 or > 130 mmHg or diastolic blood pressure (DBP) <65 or > 80 mmHg;
use of antihypertensive or cholesterol lowering medication;
history of cardiovascular or peripheral vascular disease;
diagnosed type 1 or type 2 diabetes; any major illness such as cancer; a psychiatric illness;
recent history of asthma, renal, liver or gastrointestinal disease, or gout;
use of antibiotics within previous 2 months;
current or recent (within previous 6 months) significant weight loss or gain (> 6% of body weight);
> 30g/day alcohol consumption;
woman who were pregnant, lactating or wishing to become pregnant during the study;
inability or unwillingness to consume foods provided in the trial.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Arterial stiffness measured as pulse wave velocity (PWV) using applanation tonometry (SphygmoCor pulse wave analysis system: AtCor Medical, Sydney, Australia. Model MM3. Software version 9)[Baseline and then again at 100 min and 200 min post meal]

Secondary Outcome Measures

Name	Time	Method
Arterial stiffness measured as augmentation index (AIx)using applanation tonometry (SphygmoCor pulse wave analysis system: AtCor Medical, Sydney, Australia. Model MM3. Software version 9)[Baseline and then again at 100 min and 200 min post meal];Arterial elasticity/compliance measured as the large artery elasticity index (LAEI) and the small artery elasticity index (SAEI) using pulse contour analysis of the radial artery pulse wave (HDI/Pulse wave CR-2000 instrument: Hypertension Diagnostics, Inc., Eagan, Minnesota, USA)[Baseline and then again at 140 min and 220 min post meal];Office blood pressure , mesured as systolic blood pressure, diastolic blood pressure and pulse pressure (Dinamap 1846SX/P oscillometric recorder: Critikon Inc., Tampa, FL, USA).[Baseline and then every 30 minutes to 210 minutes post meal];Salivary nitrate and nitrite concentrations (measured by gas chromatography-mass spectrometry)[Baseline and then again at 120 minutes post meal]