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临床试验/NCT01043302
NCT01043302已完成不适用

Multicenter Cross Sectional Study of Primary Intestine Lymphoma: Treatment Outcome and Quality of Life

Samsung Medical Center1 个研究点 分布在 1 个国家目标入组 545 人开始时间: 2008年9月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
545
试验地点
1
主要终点
Overall survival

研究概览

简要总结

The purpose of this study is to determine whether whether surgical resection followed by chemotherapy is superior to systemic chemotherapy alone in terms of treatment outcome and quality of life (QOL) in patients with primary intestinal lymphoma.

详细描述

Intestine is the one of commonly involved extranodal sites of non-Hodgkin's lymphoma (NHL). Thus, small and large Intestine account for approximately 30-40% of primary gastrointestinal tract lymphoma. More than 70% of intestinal lymphoma presents as localized disease, and surgery such as bowel resection is performed in many patients with intestinal lymphoma for diagnosis and treatment. However, it is still unclear whether surgical resection followed by chemotherapy is superior to systemic chemotherapy alone in terms of treatment outcome and quality of life (QOL). Thus, we analyze the clinical features and treatment outcome of patients with NHL of intestine, and at the same time perform a multicenter cross-sectional study about the QOL in survivors of intestine NHL. We evaluates the treatment outcomes of patients with intestine NHL from hospitals affiliated with the Consortium for Improving Survival of Lymphoma (CISL) in Korea. We assess the QOL of survivors who completed their treatment using the EORTC QLQ-C30 questionnaire.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
15 Years 至 85 Years(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Primary intestine lymphoma.
  • Definition of primary intestine lymphoma:
  • Dominant site should be small and large intestine with or without regional lymph node involvement
  • Distant lymph node involvement can be allowed if the intestine lesion is the presenting site
  • Contiguous involvement of other organs such as liver, spleen can be allowed

排除标准

  • Intestine involvement as a dissemination process in stage IV nodal lymphoma

结局指标

主要结局

Overall survival

时间窗: Study entry

次要结局

  • Quality of life(Study entry)

研究者

申办方类型
Other

研究点 (1)

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