Diabetes Mellitus - A Diagnosis Trial by Means of Non Invasive Measurements
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Pulse wave arrival time difference between finger and toe, duration of diabetes
研究概览
简要总结
Vascular damage caused by diabetes mellitus, cigarette smoking, age and arterial hypertension theoretically changes pulse wave velocity.
详细描述
Diabetes mellitus related vascular alterations are associated with an increased risk of hypertonia, atherosclerosis, neuropathy, diabetic retinopathy, and further more.
Increased vascular rigidity, which is based on the increased stiffness of vessels caused by vascular damage leads to an increase of pulse wave velocity. This assumption is based on the Moens-Korteweg-equation which is calculated using the modus of arterial vessel elasticity, arterial vessel wall thickness, the arterial radius and blood viscosity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients over 18 years
排除标准
- •Diabetic foot gangrene
- •No possibility of pulse wave velocitiy measurement on the finger or toe
结局指标
主要结局
Pulse wave arrival time difference between finger and toe, duration of diabetes
时间窗: 1 Minute data recording of the pulse waves at four sites.
The pulse wave is recorded by plethysmography using a pulse-oximeter and a continuous noninvasive arterial blood pressure measurement (CNAP-500) device, both on the finger and toe. The time between these 4 recorded waves is then calculated. The influence of age, duration of known arterial hypertension, cigarette smoking (pack-years) and diabetes mellitus.
次要结局
未报告次要终点
研究者
Wolfgang SCHRAMM
Ao Univ. Prof. Dr.
Medical University of Vienna