The Effect of Progesterone Induced Endometrial Compaction on Pregnancy Outcomes in Frozen-thawed Embryo Transfer at the Blastocyst Stage
Overview
- Phase
- Not Applicable
- Intervention
- Progesterone
- Conditions
- Infertility
- Sponsor
- Akdeniz University
- Enrollment
- 205
- Locations
- 1
- Primary Endpoint
- ongoing pregnancy rates.
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The purpose of this prospective cohort study is to assess the effect of endometrial compaction caused by progesterone effect on pregnancy outcomes
Detailed Description
For a pregnancy to occur, the embryo must implant in a receptive endometrium during the window of implantation, which is thought to occur from day 22 to 24 of an idealized 28-day cycle. Early studies have suggested that assessing endometrial thickness with the use of ultrasound may be an alternative to invasive techniques such as endometrial biopsy for attempting to determine a receptive endometrium for frozen-thawed embryo transfer (FET). A preovulatory endometrial thickness of 7 mm or more is considered to be the cutoff for endometrial receptivity, below which many physicians would cancel an embryo transfer. However, in most studies in the literature, endometrial thickness was measured either on the day of hCG in fresh embryo transfer cases or on the last day of estrogen treatment in thawed embryo transfers. There are a limited number of studies evaluating the luteal period, embryo transfer day and endometrial thickness. Accordingly, in this prospective cohort study is to assess the effect of endometrial compaction caused by progesterone effect on pregnancy outcomes
Investigators
ŞAFAK OLGAN
ASSOCIATE PROFESSOR
Akdeniz University
Eligibility Criteria
Inclusion Criteria
- •Woman aged 18-40 years
- •Presence of high quality (\>2BB) blastocyst
- •Hormonal(estrogen and progesterone) frozen- thawed embryo transfer cycles
- •presence of high quality blastocyst cryopreserved by vitrification method.
- •A single embryo transfer
Exclusion Criteria
- •Presence of uterine pathology
- •Participants whose optimal endometrial image cannot be obtained due to uterine position
- •Participants whose treatments were canceled for any reason before embryo transfer
- •Participants which had embryo transfer on the day 2 or 3 (at the cleavage stage)
- •Participants who had 2 embryo transfer
- •Presence of low quality (\<2BB) blastocyst
- •\> 15% loss of viability in the embryo during embryo thawing
Arms & Interventions
with endometrial compaction
Participants who have endometrial compaction caused by progesterone effects on undergoing frozen embryo transfer with artificial hormone replacement
Intervention: Progesterone
without endometrial compaction
Participants who have not endometrial compaction caused by progesterone effects on undergoing frozen embryo transfer with artificial hormone replacement
Intervention: Progesterone
Outcomes
Primary Outcomes
ongoing pregnancy rates.
Time Frame: 1 year
pregnancy beyond 12 weeks of gestational age.
The change in endometrial thickness
Time Frame: 1 year
changing in millimeters of endometrial thickness at the end of the estrogen phase and the day of embryo transfer.
Secondary Outcomes
- Clinical pregnancy rate(6-7 weeks after the last menstrual period of the patient)
- The Correlation of Serum Progesterone Levels With the Degree of Endometrial Compaction on the Day of Frozen Embryo Transfer(On the day of frozen embryo transfer)
- Clinical miscarriage(after 5th gestational week)
- Implantation rate(5 weeks after the last menstrual period of the patient)