The Effect of Progesterone on Human Endometrium

Completed

• Conditions: Fertility
• Interventions: Genetic: Microarray

• Registration Number: NCT04323683
• Lead Sponsor: University of Nottingham

Brief Summary

This study evaluates the relationship between progesterone levels and endometrial gene expression

Detailed Description

Not available

Study Timeline

• Study Start: 2019-02-01
• Primary Completion: 2019-07-31
• Study Completion: 2019-07-31
• Status Verified: 2020-03
• Study First Submitted: 2020-03-24
• Study First Submitted QC: 2020-03-25
• Last Update Submitted: 2020-03-25
• Study First Posted: 2020-03-26
• Last Update Posted: 2020-03-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 12

Inclusion Criteria

• Ages 18-35, regular menstrual cycles, the cycle length between 25 and 35 days, body mass index (BMI) between 18 - 25

Exclusion Criteria

• History of infertility, history of pelvic pain or/and endometriosis, history of pelvic mass, history of hormonal therapy in the last 3 months

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Low progesterone	Microarray	Women with progesterone level below 15 ng/ml
Normal progesterone	Microarray	Women with progesterone level above 15 ng/ml

Primary Outcome Measures

Name	Time	Method
Differentially expressed genes between women with low and normal progesterone	2 months	Fold-change and p-value were used to determine differentially expressed genes using Partek software

Trial Locations

Locations (1)

Queen's medical center; 🇬🇧 Nottingham, United Kingdom