The Correlation of Serum Progesterone Levels With the Degree of Endometrial Compaction on the Day of Frozen Embryo Transfer
试验速览
- 阶段
- 不适用
- 发起方
- Cem Demirel
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Ongoing pregnancy rates
研究概览
简要总结
This study is intended to determine whether there is a correlation between endometrial compaction and serum progesterone levels on the day of frozen embryo transfers by using transvaginal sonography for the endometrial assessment.
详细描述
This study is planned to be conducted by prospectively evaluating approximately 200 frozen embryo transfers within 6 months in a single center. Patients planned to be included in the study are started estrodiol 6 mg / day on day2-3 of mensturation. 12 days after the start of estrogen, patients who have endometrial thickness over 7 mm are then started vaginal progesterone supplementation as per routine practice and are eventually proceeded to embryo transfer either on day 4 or 6 of progesterone supplementation. In this study investigators are intended to measure endometrial thickness transvaginally on the day of embryo transfer to accurately determine the presence of endometrial compaction, assess serum progesterone levels, evaluate any possible correlations between endometrial compaction, serum progesterone levels and pregnancy rates.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Woman aged 20-40 years
- •Hormonal(estrogen and progesterone) frozen- thawed embryo transfer cycles
- •Having available blastocyst(s) cryopreserved by vitrification method.
排除标准
- •Recurrent implantation failure
- •Recurrent pregnancy loss
- •Presence of uterine pathology
- •Requirement for fresh embryo(s);
- •Presence of any clinically relevant systemic disease contraindicated for assisted reproduction or pregnancy
- •Allergy history for relevant drugs
- •Body mass index of <18 or >38 kg/m2 at screening
- •Current breastfeeding or pregnancy
- •Refusal or inability to comply with the requirements of the protocol for any reason, including scheduled clinic visits and laboratory tests
- •Natural or modified natural cycles
结局指标
主要结局
Ongoing pregnancy rates
时间窗: 12 weeks after the last menstrual period of the patient
Presence of at least one live fetus at the end of the 12th gestational week in patients with endometrial compaction compared to patients without endometrial compaction after frozen embryo transfer
次要结局
- Clinical miscarriage rate(after 5th gestational week)
- Implantation rate(5 weeks after the last menstrual period of the patient)
- The Correlation of Serum Progesterone Levels With the Degree of Endometrial Compaction on the Day of Frozen Embryo Transfer(On the day of frozen embryo transfer)
- Clinical pregnancy rate(6-7 weeks after the last menstrual period of the patient)
研究者
Cem Demirel
professor doctor
Memorial Ataşehir Hospital