Exercise in patients with a systemic right ventricle.
Recruiting
- Conditions
- Patients with a transposition of the great arteries who have undergone a Mustard or Senning correction in the past, and patients with a congenitally corrected transposition of the great arteries.
- Registration Number
- NL-OMON26970
- Lead Sponsor
- Academic Medical Center Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 86
Inclusion Criteria
All adult (18 years old, or older) patients with an atrially switched TGA or with a ccTGA (i.e. a systemic right ventricle) are potentially eligible for this study.
Exclusion Criteria
Patients are not eligible for this study if the following exclusion criteria apply:
1. Mental or physical incapability to give informed consent;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary objective of the study is to determine whether exercise training improves maximal exercise capacity in adult patients with a systemic right ventricle due to an atrially switched TGA, or to a ccTGA.<br>
- Secondary Outcome Measures
Name Time Method The secondary objectives of the study are to determine whether exercise training:<br /><br>1. Decreases serum NT-proBNP levels;<br /><br>2. Improves health related quality of life in adult patients with a systemic right ventricle.
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie exercise-induced improvements in systemic right ventricle function post-Mustard/Senning procedures?
How does structured exercise compare to standard care in managing systemic right ventricle failure in transposition of the great arteries patients?
Are there specific biomarkers that predict exercise tolerance in adult patients with congenitally corrected transposition of the great arteries?
What adverse events are associated with exercise programs in systemic right ventricle patients and how are they managed?
What combination therapies or pharmacological agents are being explored alongside exercise for systemic right ventricle optimization in transposition of the great arteries?