Antibiotics for Prevention of SSI in Obese Women Undergoing CS
- Registration Number
- NCT03736187
- Lead Sponsor
- Ain Shams University
- Brief Summary
Effect of cephalexin plus metronidazole on SSI better than cephalexin alone in obese women undergoing CS
- Detailed Description
Comparison between efficacy of cephalexin alone and cephalexin plus metronidazole on surgical site infection in obese women undergoing CS and follow up of any signs of wound infection
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 280
Inclusion Criteria
- obese women under elective CS
Exclusion Criteria
- immunodeficient women
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Cephalexin Cephalexin Group a will receive cephalexin 1gm before skin incision intravenous Cephalexin &metronidazole Cephalexin Group b will receive cephalexin 1gm intravenous plus 1gm metronidazole rectally before skin incision
- Primary Outcome Measures
Name Time Method Wound infection One week Fever, redness, ecchymosis and tenderness
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms explain the enhanced SSI prevention with cephalexin plus metronidazole in obese women undergoing cesarean section?
How does the combination of cephalexin and metronidazole compare to standard-of-care antibiotic regimens for preventing surgical site infections in obese patients?
Are there specific biomarkers that can predict which obese women will respond best to cephalexin plus metronidazole for SSI prevention?
What are the potential adverse events associated with cephalexin plus metronidazole use in postpartum obese women and how can they be managed?
What other antibiotic combinations or alternative therapies are being explored for SSI prevention in high-risk obstetric populations such as obese women?