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Clinical Trials/NCT07198308
NCT07198308CompletedNot Applicable

Association Between Blood Glucose Indicators and Heart Rate Variability in Non-diabetic Critically Ill Patients: a Single-center Prospective Study

Shanghai Zhongshan Hospital1 site in 1 country20 target enrollmentStarted: October 1, 2025Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
20
Locations
1
Primary Endpoint
Correlation between glucagon and HRV in non-diabetic critically ill patients

Study Overview

Brief Summary

Heart rate variability (HRV) is a simple way to check how well the body's automatic nervous system is working. It does this by looking at how the heart rate changes in the electrocardiogram. HRV can be divided into time domain and frequency domain. Time domain indicators assess the tone of the autonomic nerves. Frequency domain indicators reflect the regulation of the sympathetic and parasympathetic nerves. An imbalance of the body's nervous system can be reflected by HRV. Stress hyperglycemia (SIH) is when your blood glucose levels go up because of an acute disease. This is usually related to the body's stress response, but if your blood glucose levels go up too much, it can lead to complications. A high blood sugar level caused by stress is common in intensive care units. There is a strong link between this and the death rate and how long patients stay there. There are lots of nerve endings in the pancreas. Nerve fibres control the way islet α/β cells work to keep the right amount of glucose in the blood. We know that the pancreatic nerve is important for controlling blood glucose levels, but we don't fully understand how it does this.

Study Design

Study Type
Observational
Observational Model
Case Only
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to 99 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Aged from 18 to 99 years old
  • •Informed consent has been signed

Exclusion Criteria

  • •Under 18 years old
  • •Diagnosed with diabetes either prior to or during hospitalization
  • •Missing HRV values
  • •Missing blood glucose and random insulin values

Outcomes

Primary Outcomes

Correlation between glucagon and HRV in non-diabetic critically ill patients

Time Frame: From enrollment to completion of indicator testing (within 24 hours)

Secondary Outcomes

  • The correlation between blood glucose and random insulin levels and HRV in non-diabetic critically ill patients(From enrollment to completion of indicator testing (within 24 hours))

Investigators

Sponsor
Shanghai Zhongshan Hospital
Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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