Diagnosing Chronic Intestinal Pseudo-Obstruction with dynamic MRI motility measurements

Completed

• Conditions: bowel movement disorder; Severe bowel motility disorder; 10018008

• Registration Number: NL-OMON46622
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 8

Inclusion Criteria

Willing to give informed consent
Willing to undergo MRI
18 years or older
Willing to receive a small-volume test meal either orally or via a nasogastric/duodenal tube
Diagnosed with CIPO based on symptoms of intestinal occlusion and findings at antroduodenal manometry compatible with CIPO (abnormal propagation of phase 3 or abnormally low contraction amplitudes)

Exclusion Criteria

Being unable to give informed consent
Inability to hold breath for 20 seconds
Contraindications to undergo MRI (certain neuroclips, pacemaker, claustrophobia, pregnancy)
Contraindication for ingredients in the test meal (Nutridrink Juice style apple)
Substantial risk of vomiting after intake of the test meal (which cannot be solved by placing a nasogastric or duodenal tube), as assessed by a clinician with experience treating this patient group

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the response of small bowel motility to a food<br /><br>stimulus in CIPO patients, expressed as the ratio between the postprandial<br /><br>motility score and the interdigestive motility score, measured with dynamic<br /><br>MRI. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- To evaluate if the oral intake of a small-volume test meal is feasible in<br /><br>CIPO patients or if a nasogastric/duodenal tube is necessary.<br /><br>- To assess if there are differences in interdigestive and postprandial<br /><br>motility values of CIPO patients and healthy volunteers.<br /><br>- To assess if there are differences in motility of CIPO patients with a<br /><br>neurogenic and patients with a myogenic cause of the disease. </p><br>