Does High Flow Nasal Cannula (HFNC) facilitate CO2-washout during EBUS under procedural sedation?

Phase 4

Completed

• Conditions: Sedatie; High flow nasal cannula; ventilation; 10006436; 10038737

• Registration Number: NL-OMON51455
• Lead Sponsor: Rijnstate Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 26 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Adult patients scheduled for EBUS with sedation
COPD gold class 3-4

Exclusion Criteria

- Neuromusculaire diseases, such as Guillan Barre, MS, ALS
- allergy to propofol or esketamine
- Systolic pulmonary pressure > 60 mmHg
- Pregnancy
- Children (age <18)
- Upper airway obstruction, such as stenosis or tumour

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The CO2-washout will be measured by:<br /><br>- insp CO2<br /><br>- exp CO2<br /><br>- CO2-waveform analysis</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secundary outcomes will be:<br /><br>- a difference in CO2-washout in different levels of the trachea (carina en<br /><br>left main bronchus).<br /><br>- a flow-dependency<br /><br><br /><br>There will be controlled for capillary CO2.</p><br>