Lung Ultrasonography After Laparoscopic Gynecologic Surgery

Completed

• Conditions: Pulmonary Atelectasis

• Registration Number: NCT04116567
• Lead Sponsor: SONNINO CHIARA

Brief Summary

This study evaluates the influence of surgical and anesthesia-related variable on atelectasis formation during laparoscopic gynecologic oncologic surgery by lung ultrasound.

Detailed Description

Approximately 50% of patients undergoing general anesthesia are hypoxemic. Anaesthesia, paralysis, high concentrations of oxygen, inadequate level of PEEP, capnoperitoneum, Trendelenburg position all result in persistent atelectasis. Lung ultrasound is a safe and accurate bedside tool useful to study lung aeration. The aim of the investigator's study was to assess the impact of general anesthesia and laparoscopic gynecologic oncologic surgery on post-operative atelectasis and related oxygenation changes using lung ultrasound.

Study Timeline

• Study Start: 2018-10-03
• Primary Completion: 2018-10-03
• Study Completion: 2019-06-28
• Study First Submitted: 2019-07-27
• Study First Submitted QC: 2019-10-03
• Study First Posted: 2019-10-04
• Status Verified: 2021-10
• Last Update Submitted: 2021-10-25
• Last Update Posted: 2021-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

• Patients older than 18 yo undergoing laparoscopic surgery for gynecologic surgery who provide written informed consent.

Exclusion Criteria

• age < 18 yo;
• pregnancy;
• refused to partecipate;
• known pulmonary metastasis;
• preexisting pulmonary conditions (COPD, pleural effusion, pulmonary consolidations, lung edema, pulmonary embolism);
• anesthesia with mechanical ventilation in the 2 weeks.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assess if LUS score measured after surgery is higher that LUS score measured before induction of anesthesia	The outcome will be measured 10 minutes after extubation	Each lung will be divided in 6 areas and a score from 0 to 3 will be assigned to each field depending on the loss of aereation detected by ultrasound. LUS score will range between 0 and 36. Lung ultrasound will be performed before induction of anesthesia and 10 minutes after extubation.
Correlation between the increase of LUS score after surgery and surgical or anesthesia-related variables.	The outcome will be measured 10 minutes after extubation	Logistic regression will be applied to consider the correlation between Delta LUS and the following variables: * lenght of surgery; * duration of pneumoperitoneum; * angle of Trendelenburg potision; * duration of mechanical ventilation; * intraoperative fluids; * duration of apnea from induction to intubation

Trial Locations

Locations (1)

IRCCS Fondazione Policlinico Universitario Agostino Gemelli; 🇮🇹 Rome, Italy