REDUCE Programme WS4: REviewing long term anti-DEpressant Use by Careful monitoring in Everyday practice

Not Applicable

Completed

• Conditions: Depression; Mental and Behavioural Disorders; Long-term use of antidepressants for depression

• Registration Number: ISRCTN15036829
• Lead Sponsor: niversity of Southampton

Brief Summary

2020 Protocol article in https://pubmed.ncbi.nlm.nih.gov/32448374/ (added 04/10/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-09-12
• Study Completion: 2019-10-31
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

1. Aged 18 years and over
2. On antidepressant treatment for more than 1 year for a first episode
3. Treated for more than 2 years for a recurrent episode
4. No longer depressed or judged to be at significant risk of relapse

Exclusion Criteria

1. Significant risk factors for relapse, including:
1.1. Current significant depressive symptoms on the PHQ-9 (score 12+) despite antidepressant treatment
1.2. Current significant anxiety symptoms on the GAD-7 (score 10+)
1.3. Current suicidal ideas
1.4. Depression needing current psychiatric outpatient or inpatient treatment
2. Bipolar disorder, comorbid psychosis, substance use, or dementia as a primary diagnosis
3. Spoken or written English language inadequate to take part in interviews or complete questionnaires
4. Another indication for taking antidepressants, e.g. neuropathic pain

Study & Design

• Study Type: Interventional
• Study Design: Not specified