Trial of Internet and telephone support to people coming off long-term antidepressants
- Conditions
- Mood [affective] disordersMental and Behavioural Disorders
- Registration Number
- ISRCTN12417565
- Lead Sponsor
- niversity of Southampton
- Brief Summary
2020 Protocol article in https://pubmed.ncbi.nlm.nih.gov/32448374/ protocol (added 26/05/2020) 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/38913372/ (added 25/06/2024)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 330
1. Patients who are taking long-term antidepressant treatment, which is not indicated according to the NICE depression guideline (NICE, 2009):
1.1 Treated for more than 1 year for a first episode, and
1.2 Treated for more than 2 years for a recurrent episode, who are:
1.3 No longer depressed or judged to be at significant risk of relapse
2. Adults over 18 years
1. At risk for relapse:
1.1 Current significant depressive symptoms on the PHQ-9 (see below) despite antidepressant treatment
1.2 Current significant anxiety symptoms on the GAD-7
1.3 Current suicidal ideas
1.4 Current psychiatric outpatient or inpatient treatment for depression
2. Bipolar disorder, comorbid psychosis, substance use, or dementia as a primary diagnosis
3. Spoken or written English language inadequate to take part in interviews or complete questionnaires
4. Another indication for taking antidepressants, e.g. neuropathic pain
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Depression measured by PHQ-9 score at baseline and 6 months
- Secondary Outcome Measures
Name Time Method