The Haemodynamic Effects of Mechanical Standard and Active Chest Compression-decompression During Out-of-hospital CPR

Not Applicable

Completed

• Conditions: Cardiac Arrest
• Interventions: Device: LUCAS2 AD

• Registration Number: NCT02479152
• Lead Sponsor: Physio-Control

Brief Summary

The aim of this randomized out-of-hospital cardiopulmonary resuscitation study is to investigate haemodynamics generated by the standard mechanical external chest compression device (LUCAS™ 2) compared to a new version generating chest compressions and active decompression above the initial starting position of the suction cup (LUCAS™ 2AD).

Detailed Description

Based on randomization patients will receive standard or active compression decompression chest compression and the haemodynamic effects will be compared.

Study Timeline

• Study Start: 2015-04
• Study First Submitted: 2015-04-13
• Study First Submitted QC: 2015-06-23
• Study First Posted: 2015-06-24
• Primary Completion: 2017-04
• Study Completion: 2017-04
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-02
• Last Update Posted: 2017-08-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 126

Inclusion Criteria

• Unexpected adult out-of-hospital non-traumatic cardiac arrest where an attempt of resuscitation is considered appropriate in:
• Patients 18 years or older

Exclusion Criteria

• Traumatic cardiac arrest
• Age believed to be less than 18 years
• Known pregnancy
• Victim not to be resuscitated (DNR orders)
• Internals in prison
• Included once in the study already
• To Small/Large patients
• Sustained ROSC occurring before the LUCAS™ 2 or LUCAS™ 2-AD can be applied to the patient, such that further CPR is not needed

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
LUCAS 2 AD	LUCAS2 AD	LUCAS 2 AD will be used for CPR
LUCAS2	LUCAS2 AD	LUCAS2 will be used for CPR

Primary Outcome Measures

Name	Time	Method
Hemodynamics measured as EtCO2	During 30 minutes of CPR

Secondary Outcome Measures

Name	Time	Method
Intra arterial blood pressures,	During 30 minutes of CPR
Oximetry,	During 30 minutes of CPR
ROSC (Return of spontaneous circulation)	During CPR
safety	During 30 minutes of CPR

Trial Locations

Locations (1)

Oslo University hospital; 🇳🇴 Oslo, Norway