Uric Acid Levels and Endothelial Functions

Completed

• Conditions: Coronary Artery Disease
• Interventions: Other: Questionnaire of overall health

• Registration Number: NCT02862522
• Lead Sponsor: Mayo Clinic

Brief Summary

Uric acid is a risk factor for coronary artery disease (CED) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction is not well-defined. The aim of this study was to determine the relationship of serum uric acid, inflammatory markers and CED.

Detailed Description

Not available

Study Timeline

• Study Start: 1992-01
• Primary Completion: 2016-02
• Study Completion: 2016-02
• Status Verified: 2016-08
• Study First Submitted: 2016-08-08
• Study First Submitted QC: 2016-08-08
• Last Update Submitted: 2016-08-08
• Study First Posted: 2016-08-11
• Last Update Posted: 2016-08-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 229

Inclusion Criteria

• Referred to Mayo Clinic for cardiac catheterization
• Postmenopausal

Exclusion Criteria

• History of percutaneous coronary intervention
• Coronary artery bypass graft surgery
• Unstable angina pectoris
• Valvular heart disease
• Peripheral vascular disease
• Known congestive heart failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Women With CED	Questionnaire of overall health	All subjects had blood work with included measurement of C-reactive protein, complete blood count with differential, basic chemistry panel, and uric acid level. All subjects completed a standardized questionnaire to assess baseline characteristics. All subjects underwent comprehensive coronary endothelial function assessment. Subjects completed a questionnaire of overall health several years after the index coronary angiogram and endothelial function study.
Women Without CED	Questionnaire of overall health	All subjects had blood work with included measurement of C-reactive protein, complete blood count with differential, basic chemistry panel, and uric acid level. All subjects completed a standardized questionnaire to assess baseline characteristics. All subjects underwent comprehensive coronary endothelial function assessment. Subjects completed a questionnaire of overall health several years after the index coronary angiogram and endothelial function study.

Primary Outcome Measures

Name	Time	Method
Serum Uric Acid Level	Baseline

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States