Can Preanesthetic Analgesia/Nociception Index (ANI) Predict Propofol Injection Pain
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pain, Acute
- Sponsor
- Wonkwang University Hospital
- Enrollment
- 124
- Locations
- 1
- Primary Endpoint
- The correlation of Analgesia/nociception Index (ANI) and Propofol injection pain (PIP)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Recently, Analgesia Nociception Index (ANI) has been evaluated for objectively measuring peri-operative pain and to guide intra-operative opioid administration during various surgeries.
Propofol injection pain (PIP) is a common problem and can be very distressing to the patient.
Detailed Description
This study aimed to the association of preanesthetic ANI scores and PIP in patients who scheduled for general anesthesia. Before propofol administration in remifentanil group, preanesthetic ANI values (instant and mean) were checked after remifentanil to a target Ce of 4 ng/ml. Control group received the same volume of saline as remifentanil group. Heart rate and bispectral index were checked as ANI. Point biserial correlation and ROC curve were analyzed.
Investigators
Cheol Lee,MD,PhD,
Professor
Wonkwang University Hospital
Eligibility Criteria
Inclusion Criteria
- •Male patients who scheduled for general anesthesia
- •Cognitive patients who could understand this study
Exclusion Criteria
- •Patients receiving β-receptor blockers, ketamine, clonidine, or any vasoactive substance (i.e. metaraminol, ephedrine) and patients receiving neostigmine, atropine or glycopyrrolate.
Outcomes
Primary Outcomes
The correlation of Analgesia/nociception Index (ANI) and Propofol injection pain (PIP)
Time Frame: Immediately before administration of propofol (2mg/kg)
The correlation of preanesthetic ANI scores and incidence of PIP.
Secondary Outcomes
- Incidence and severity of PIP(during anesthesia induction ( half-dose (1mg/kg) and full-dose of (2mg/kg) propofol administration))
- The correlation of Analgesia/nociception Index (ANI) and Propofol injection pain (PIP)(Immediately before administration of propofol (2mg/kg))