Non-invasive Assessment of Immediate Postoperative Analgesia Using Analgesia/Nociception Index (ANI): A Prospective and Observational Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Pain
- Sponsor
- Hôpital Edouard Herriot
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Pain Scores on a 0-10 Numeric Rating Scale (NRS)
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
The aim of this study is to evaluate the clinical performance on Analgesia/Nociception Index (ANI) in the assessment of immediate postoperative analgesia in PACU in adult patients undergoing general anesthesia.
Detailed Description
Evaluation of the relationship between ANI and numerical rating pain scale (NRS) by linear regression. Assessment of the performance of ANI to detect NRS\>3 and NRS\>=7 by building ROC curves.
Investigators
Emmanuel Boselli
MD, PhD
Hôpital Edouard Herriot
Eligibility Criteria
Inclusion Criteria
- •surgical or endoscopic procedures performed on general anesthesia
Exclusion Criteria
- •age \<18 yrs or \>75 yrs
- •arrythmia
- •administration of anticholinergic drugs or neuromuscular blockade reversal in the 20 previous minutes
- •psychiatric diseases
- •autonomic nervous system (ANS) disorders
- •inability to understand the verbal rating pain scale.
Outcomes
Primary Outcomes
Pain Scores on a 0-10 Numeric Rating Scale (NRS)
Time Frame: At arrival in PACU or 10 min after extubation
Verbal pain scale, with 0 = no pain and 10 = worst pain imaginable. NRS\<3 corresponds to no or mild pain NRS\>=3 corresponds to moderate to severe pain NRS\>=7 corresponds to severe pain
Analgesia/Nociception Index (ANI)
Time Frame: At arrival in post-operative care unit (PACU) or 10 min after extubation
The ANI is a 0-100 index estimating the parasympathetic/sympathetic balance derived from heart rate variability, measured by the PhysioDoloris monitor (MetroDoloris, Loos, France). High ANI values indicate parasympathetic predominance (no pain) while during nociception (increase in sympathetic activity), ANI value decrease to 60 or less.