Comparison of two drug combination for Laparoscopic Cholecystectomy for post operative pain relief

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2022/01/039789
• Lead Sponsor: Dr Alok Kumar

Brief Summary

Post operative pain management is one of the most crucial step in a health care system. Opioid  such as remifentanil are being used extensively. However  its use are associated with many side effect like respiratory depression, chest wall rigidity, nausea, vomiting, drowsiness, pruritis, urinary retention, immunomodulation and post operativehyperalgesia(a paroxidal side effect of opioid).

Alternative drugs are being studied and lignocaine and magnesium sulphate has been chosen for its lesser side effect and more beneficial. Systemic lignocaine is associated with less post operative pain due to its antinociceptive, antihyperanalgesia and antiinflamatory properties making lesser use of analgesia and general anaesthetic.

On the other hand magnesium sulphate is NMDA receptor blocker that can prevent central sensitization after peripheral lesion or inflammation in the tissue because of inhibition of NMDA Receptor in the dorsal horn of spinal cord. In this study we compare the effectiveness of intravenous Lignocaine with intravenous Lignocaine and Magnesium sulphate combination for laparoscopic Cholecystectomy.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-01-27
• Study Start: 2022-01-31

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• 1)Patients aged 18 to 50 years of both sex undergoing laproscopic cholecystectomy under general anesthesia.
• 2)ASA 1 and 2.
• 3)Consenting patients.

Exclusion Criteria

1)Patient refusal 2)ASA 3 & 4 3)Allergy to drugs 4)Seropositive and COVID 19 positive.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1)Quality of recovery score in post operative laproscopic cholecystectomy over 24 hours	1)Quality of recovery score in post operative laproscopic cholecystectomy over 24 hours | 2)To compare post-operative analgesia in the group with lignocaine and a group with combination of lignocaine and magnesium sulphate by NRS score at 0, 2, 4, 12 and 24 hour.
2)To compare post-operative analgesia in the group with lignocaine and a group with combination of lignocaine and magnesium sulphate by NRS score at 0, 2, 4, 12 and 24 hour.	1)Quality of recovery score in post operative laproscopic cholecystectomy over 24 hours | 2)To compare post-operative analgesia in the group with lignocaine and a group with combination of lignocaine and magnesium sulphate by NRS score at 0, 2, 4, 12 and 24 hour.

Secondary Outcome Measures

Name	Time	Method
To compare hemodynamics between the two groups intra-operatively and post operatively.	Intar-operative and post- operative for 24 hours

Trial Locations

Locations (1)

IGIMS , Sheikpura, Patna; 🇮🇳 Patna, BIHAR, India

IGIMS , Sheikpura, Patna

🇮🇳Patna, BIHAR, India

Dr Alok Kumar

Principal investigator

9028300731

alok4138starex@gmail.com