Comparison of intravenous lignocaine with intravenous lignocaine and Magnesium Sulphate combination for Laparoscopic Cholecystectomy
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- 1)Quality of recovery score in post operative laproscopic cholecystectomy over 24 hours
研究概览
简要总结
Post operative pain management is one of the most crucial step in a health care system. Opioid such as remifentanil are being used extensively. However its use are associated with many side effect like respiratory depression, chest wall rigidity, nausea, vomiting, drowsiness, pruritis, urinary retention, immunomodulation and post operativehyperalgesia(a paroxidal side effect of opioid).
Alternative drugs are being studied and lignocaine and magnesium sulphate has been chosen for its lesser side effect and more beneficial. Systemic lignocaine is associated with less post operative pain due to its antinociceptive, antihyperanalgesia and antiinflamatory properties making lesser use of analgesia and general anaesthetic.
On the other hand magnesium sulphate is NMDA receptor blocker that can prevent central sensitization after peripheral lesion or inflammation in the tissue because of inhibition of NMDA Receptor in the dorsal horn of spinal cord. In this study we compare the effectiveness of intravenous Lignocaine with intravenous Lignocaine and Magnesium sulphate combination for laparoscopic Cholecystectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients aged 18 to 50 years of both sex undergoing laproscopic cholecystectomy under general anesthesia.
- •ASA 1 and
- •Consenting patients.
排除标准
- •Patient refusal 2)ASA 3 & 4 3)Allergy to drugs 4)Seropositive and COVID 19 positive.
结局指标
主要结局
1)Quality of recovery score in post operative laproscopic cholecystectomy over 24 hours
时间窗: 1)Quality of recovery score in post operative laproscopic cholecystectomy over 24 hours | 2)To compare post-operative analgesia in the group with lignocaine and a group with combination of lignocaine and magnesium sulphate by NRS score at 0, 2, 4, 12 and 24 hour.
2)To compare post-operative analgesia in the group with lignocaine and a group with combination of lignocaine and magnesium sulphate by NRS score at 0, 2, 4, 12 and 24 hour.
时间窗: 1)Quality of recovery score in post operative laproscopic cholecystectomy over 24 hours | 2)To compare post-operative analgesia in the group with lignocaine and a group with combination of lignocaine and magnesium sulphate by NRS score at 0, 2, 4, 12 and 24 hour.
次要结局
- To compare hemodynamics between the two groups intra-operatively and post operatively.(Intar-operative and post- operative for 24 hours)