High Intensity Interval Training in Chronic Stroke

Not Applicable

Completed

• Conditions: Stroke
• Interventions: Other: High-intensity interval training (HIT); Other: Traditional Aerobic Training

• Registration Number: NCT01958606
• Lead Sponsor: University of Cincinnati

Brief Summary

The objective of this study was to compare the effectiveness of high intensity interval training (HIT) and traditional aerobic training for persons with stroke.

Detailed Description

Participants were randomized to either HIT or traditional aerobic training; each 25 minutes, 3 times per week for 4 weeks. Outcomes were measured before and after training by a blinded rater.

Study Timeline

• Study Start: 2013-10
• Study First Submitted: 2013-10-07
• Study First Submitted QC: 2013-10-07
• Study First Posted: 2013-10-09
• Primary Completion: 2014-08
• Study Completion: 2014-08
• Results First Submitted: 2017-02-12
• Results First Submitted QC: 2017-02-12
• Results First Posted: 2017-03-29
• Status Verified: 2017-04
• Last Update Submitted: 2017-04-08
• Last Update Posted: 2017-05-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• 1. age 35-90 years
• 2. unilateral stroke experienced >6 months prior to enrollment
• 3. able to walk 10m overground with assistive devices as needed and no physical assistance
• 4. able to walk 3 minutes on the treadmill at >.13m/s (0.3mph) with no aerobic exercise contraindications
• 5. stable cardiovascular condition (American Heart Association class B, allowing for aerobic capacity <6 metabolic equivalents)
• 6. discharged from formal rehabilitation

Exclusion Criteria

• 1. significant resting ECG abnormalities
• 2. evidence of significant arrhythmia or myocardial ischemia on treadmill ECG stress test
• 3. hospitalization for cardiac or pulmonary disease within 3 months
• 4. pacemaker or implanted defibrillator
• 5. lower extremity claudication
• 6. unable to communicate with investigators or correctly answer consent comprehension questions
• 7. severe lower extremity spasticity (Ashworth >2)
• 8. lower extremity weight bearing pain >4/10 on visual analogue scale

For the transcranial magnetic stimulation substudy, additional exclusions will also be applied. These include large cerebral infarcts or other structural defects with the potential to increase seizure risk, uncontrolled seizures, metal implants and previous craniotomy.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High-intensity interval training (HIT)	High-intensity interval training (HIT)	Treadmill exercise using bursts of concentrated effort alternated with recovery periods
Traditional aerobic training	Traditional Aerobic Training	Moderate intensity continuous aerobic exercise on a treadmill

Primary Outcome Measures

Name	Time	Method
Change in Peak Aerobic Capacity (VO2-peak)	Baseline and 4 weeks

Secondary Outcome Measures

Name	Time	Method
Change in Submaximal Aerobic Capacity (VO2 at Ventilatory Threshold)	Baseline and 4 weeks
Change in Gait Velocity (10 Meter Walk Test)	Baseline and 4 weeks
Change in 6-Minute Walk Test	Baseline and 4 weeks	distance walked in 6 minutes
Change in Gait Economy (Mean Oxygen Uptake at Comfortable Walking Speed)	Baseline and 4 weeks	mean oxygen uptake at comfortable walking speed reported in units mLO2 per kilogram body weight per meter
Change in Fastest Treadmill Speed (Steep Ramp Test)	Baseline and 4 weeks	fastest safe treadmill walking speed
Change in Fractional Utilization	Baseline and 4 weeks	Metabolic cost of gait as a percentage of aerobic capacity

Trial Locations

Locations (1)

University of Cincinnati; 🇺🇸 Cincinnati, Ohio, United States