Pilot study in gait perturbations in patients with chronic obstructive pulmonary disease

Completed

• Conditions: chronic bronchitis; chronic obstructive pulmonary disease (COPD); emphysema; 10006436

• Registration Number: NL-OMON45605
• Lead Sponsor: Ciro

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2019-06-04
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

Older healthy adults:
- Healthy subjects
- Aged between 50-80 years old
- No known musculoskeletal disease, condition or injury that could negatively affect walking or balance ability
- No history of balance problems, dizziness or walking difficulties
- Must be able to walk at comfortable speed for 30 minutes without stopping
- Informed consent given;Patients with COPD
- Main diagnosis is COPD, diagnosed at CIRO (FEV1/FVC <0.70)
- Aged between 50-80 years old
- Must be able to perform the 6-minute walk test without a stop and without the use of walking aids
- Must be stable: no exacerbation of COPD, defined as an acute event characterized by a worsening of the patient*s respiratory symptoms that is beyond normal day-to-day variations and leads to a change in medication, within 4 weeks to data collection
- No chronic oxygen use
- Informed consent given

Exclusion Criteria

- musculoskeletal disease, condition or injury
- subject is unable to walk without walking aids
- subject is unable to perform the 6-minute walk test without a stop
- subject with open wounds
- subject with balance problems, dizziness or walking difficulties (for healthy older adults)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the reactive adaptation potential measured during<br /><br>the locomotor plasticity assessment protocol with the Gait Real-time Analysis<br /><br>Interactive Lab. This will be calculated as the magnitude of change in the<br /><br>margin of stability at touchdown of the first step after the perturbation<br /><br>before and after repetition of the perturbation. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Walking speed, step width, step length, cadence at touchdown of the first and<br /><br>following recovery steps after each perturbation.</p><br>