Physical Activity and Lipid Content of Coronary Artery Atheromatous Plaques: a Randomised Trial Using Novel Intracoronary Imaging Techniques
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronary Disease
- Sponsor
- Norwegian University of Science and Technology
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- lipid content of atherosclerotic coronary artery plaques
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The primary purpose of this study is to investigate if systematic, high intensity, interval-based aerobic exercise training results in regression of lipid content of atherosclerotic coronary artery plaques, and in reduction of plaque burden in patients with stable coronary heart disease. Composition and morphologic characteristics of plaques will be studied by intra-coronary near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) in patients undergoing percutaneous coronary intervention.
Investigators
Eligibility Criteria
Inclusion Criteria
- •stable coronary artery disease
- •will undergo cardiac catheterization
- •will be treated with percutaneous coronary intervention (PCI)
- •signed written informed consent
- •able to execute the intervention
Exclusion Criteria
- •earlier bypass surgery
- •known inflammatory disease other than atherosclerosis
- •planned surgery within 4 months
- •included in another randomized controlled study
Outcomes
Primary Outcomes
lipid content of atherosclerotic coronary artery plaques
Time Frame: 6 months
Lipid core burden index (LCBI) measured by intracoronary near-infrared spectroscopy