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Clinical Trials/NCT02494947
NCT02494947
Completed
Not Applicable

Physical Activity and Lipid Content of Coronary Artery Atheromatous Plaques: a Randomised Trial Using Novel Intracoronary Imaging Techniques

Norwegian University of Science and Technology1 site in 1 country60 target enrollmentFebruary 2016

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Coronary Disease
Sponsor
Norwegian University of Science and Technology
Enrollment
60
Locations
1
Primary Endpoint
lipid content of atherosclerotic coronary artery plaques
Status
Completed
Last Updated
6 years ago

Overview

Brief Summary

The primary purpose of this study is to investigate if systematic, high intensity, interval-based aerobic exercise training results in regression of lipid content of atherosclerotic coronary artery plaques, and in reduction of plaque burden in patients with stable coronary heart disease. Composition and morphologic characteristics of plaques will be studied by intra-coronary near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) in patients undergoing percutaneous coronary intervention.

Registry
clinicaltrials.gov
Start Date
February 2016
End Date
April 2019
Last Updated
6 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • stable coronary artery disease
  • will undergo cardiac catheterization
  • will be treated with percutaneous coronary intervention (PCI)
  • signed written informed consent
  • able to execute the intervention

Exclusion Criteria

  • earlier bypass surgery
  • known inflammatory disease other than atherosclerosis
  • planned surgery within 4 months
  • included in another randomized controlled study

Outcomes

Primary Outcomes

lipid content of atherosclerotic coronary artery plaques

Time Frame: 6 months

Lipid core burden index (LCBI) measured by intracoronary near-infrared spectroscopy

Study Sites (1)

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