Physical Activity and Lipid Content of Coronary Artery Atheromatous Plaques: a Randomised Trial Using Novel Intracoronary Imaging Techniques
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- lipid content of atherosclerotic coronary artery plaques
研究概览
简要总结
The primary purpose of this study is to investigate if systematic, high intensity, interval-based aerobic exercise training results in regression of lipid content of atherosclerotic coronary artery plaques, and in reduction of plaque burden in patients with stable coronary heart disease. Composition and morphologic characteristics of plaques will be studied by intra-coronary near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) in patients undergoing percutaneous coronary intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •stable coronary artery disease
- •will undergo cardiac catheterization
- •will be treated with percutaneous coronary intervention (PCI)
- •signed written informed consent
- •able to execute the intervention
排除标准
- •earlier bypass surgery
- •known inflammatory disease other than atherosclerosis
- •planned surgery within 4 months
- •included in another randomized controlled study
研究组 & 干预措施
interval training
high intensity interval-based aerobic exercise
干预措施: high intensity interval-based aerobic exercise (Behavioral)
interval training
high intensity interval-based aerobic exercise
干预措施: Usual care (Other)
controls
usual care
干预措施: Usual care (Other)
结局指标
主要结局
lipid content of atherosclerotic coronary artery plaques
时间窗: 6 months
Lipid core burden index (LCBI) measured by intracoronary near-infrared spectroscopy
次要结局
未报告次要终点